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Ítem Acceso Abierto A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period(PLOS, 2019-10-31) Parodi, Roberto Leandro; Lagrutta, Mariana; Tortolo, Mauro; Navall, Estefanía; Rodríguez, María S.; Sasia, Gervasio Flavio; de Candia, Lucas F.; Gruvman, Matias A.; Bottasso, Oscar; Greca, Alcides AlejandroÍtem Acceso Abierto Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models(Future Science Group, 2020-01-23) Giolito, Maria Virginia; Camacho, Cristian M.; Martinez-Amezaga, Maitena; Traficante, Carla Inés; Giordano, Rocío A.; Cornier, Patricia G.; Mata, Ernesto G.; Delpiccolo, Carina M.L.; Boggián, Dora G.; Del Giúdice, Antonela; Mainetti, Leandro Ernesto; Scharovsky, Olga Graciela; Rozados, Viviana R.; Rico, María JoséÍtem Acceso Abierto Achievements and challenges in the use of metronomics for the treatment of breast cancer(Elsevier, 2020-03) Scharovsky, O. Graciela; Rico, María José; Mainetti, Leandro Ernesto; Perroud, Herman A; Rozados, Viviana R.Ítem Acceso Abierto Study of non-linear viscoelastic behavior of the human red blood cell(arXiv.org, 2018) Castellini, Horacio V.; Riquelme, Bibiana DorisÍtem Acceso Abierto Chikungunya fever. A new global threat(Elsevier España, 2015-08) Montero, AntonioÍtem Embargo Study of the red blood cell aggregation by coherent anti-Stokes Raman spectroscopy(Natan T. Shaked y Oliver Hayden, 2020-02-20) Toderi, Martín A.; Galizzi, Gustavo E.; Riquelme, Bibiana Doris; Dumas, Dominique; Society of Photo-optical Instrumentation Engineers (SPIE)In this work, we studied the nature of the molecular bonds involved in the red blood cell aggregation process by the coherent anti-Stokes Raman spectroscopy technique. Images were acquired with a commercial Leica TCS SP8 CARS confocal microscope (Leica Microsystems GmbH, Wetzlar, Germany) temporally and spatially overlapping the pulses of two sources in the focal plane of the microscope. A pump wavelength of 810 nm to 817 nm was used for the CARS mode simultaneously with the Stokes beam at 1064 nm to excite the vibratory resonance of the symmetric hydrocarbon bonds in the lipids and that of the bonds in amino acids of the proteins. The Raman shift was also observed at the 1200 cm−1 range to study possible variations in the sialic acid on the cell membrane produced by concentrations of dextran 500 in the suspension medium. Curves of lifetime emission distribution were obtained for untreated erythrocytes and treated erythrocytes with dextran 500, particularly at a pump wavelength of 904 nm.Ítem Acceso Abierto Alterations of the erythrocyte membrane by in vitro action of Trichinella spiralis muscle larvae(Cambridge University Press, 2018-11-29) Ponce de León, Patricia; Bellini, Mariana; Castellini, Horacio V.; Riquelme, Bibiana DorisÍtem Acceso Abierto In Vitro effect if trigonelline on the erythrocyte aggregation in a model of diabetes(2019-06) Riquelme, Bibiana Doris; Mascaro Grosso, Hermano; Toderi, Martin A.; Buszniez, Patricia; D’Arrigo, Mabel; Sociedade Brasileira de BiofísicaIntroduction: In the last few decades, a large number of medicinal plants popularly used for the treatment of diabetes have been studied around the world (Chang et al., 2013). The chemical characterization of plant components and the biological, pharmacological or toxicological activity of different plant extracts have been well studied; however, more research is necessary on the relationship between phytochemical components and their specific therapeutic action. Trigonelline is an alkaloid present in the leaves of Bauhinia sp., popularly known as “cow-hoof”, and also in coffee and fenugreek seeds, which were used as an antidiabetic treatment by ancient civilizations. It has been found to reduce hyperglycemia, both in animals and humans, to protect pancreatic β-cells, and to increase the rate of insulin sensitivity (Toloza-Zambrano et al., 2015).Ítem Acceso Abierto Preliminary study of alterations in human red blood cells by irradiation with high energy photons(Blucher, 2019) Riquelme, Bibiana Doris; Estrada, Ezequiel; Castellini, Horacio V.; Acosta, Andrea; Chinelatto, Alejandro; Tack, Ivan; Borraz, Javier; Di Tullio, Liliana; Galassi, Mariel Elisa; Sociedade Brasileira de Biofísica; D'Arrigo, Mabel. Colaboración en preparación de muestras biológicas; Castellani, Daniel. Colaboración en la fabricación del dispositivo adaptador de muestra.Introduction: Transfusion-associated graft-versus-host disease can be prevented by treating cellular blood products with gamma irradiation. A wide range of gamma irradiation dose levels are used in routine practice, but gamma irradiation dose of 25 Gy may be required to completely inactivate T cells in Red Blood Cells (RBC) units (Pelszynski, M. et al., 1994). This process decreases the survival of the RBC transfused, so it is crucial to understand the alterations caused by gamma irradiation to the erythrocyte membrane. In previous works, the biochemical and hematological effects of gamma irradiation at different storage periods were studied. It was observed that irradiation of the erythrocytes increases red cells hemolysis and leakage of intracellular potassium (Adams, F. et al., 2015; Yousuf, R. et al., 2018). The mechanisms through which irradiation causes the loss of RBC viability could be related to the primary effects of radiation. Gamma and X-ray Ionizing radiation cause indirect damage through the reactive oxygen species generated by water radiolysis (Anand, A.J. et al., 1997). The reduced deformability of RBC after irradiation could be related to the interaction of the oxygen-derived radicals with the membranes, affecting their mechanical properties and leading to deformability impairment (Kim, Y.-K. et al., 2008). In a recent work (AlZahrani K. et al., 2017), nanoestructural changes in the RBC membrane at different doses of gamma irradiation were observed using atomic force microscopy. The images shown that the roughness of the cell membrane increased dramatically with increasing doses, affecting their biophysical properties. However, more research is needed to understand the effects of gamma irradiation on the mechanical and adhesion properties of RBC. For this reason, in the present work we set out to measure the mechanical and aggregation parameters of human red blood cells exposed to gamma photons in different doses in order to determine the possible alterations due to radiation.Ítem Acceso Abierto An experimental approach to study the red blood cell dynamics in a capillary tube by biospeckle laser(Elsevier, 2019) Toderi, Martín A.; Riquelme, Bibiana Doris; Galizzi, Gustavo E.; D'Arrigo, Mabel. Colaboración en preparación de muestras biológicas; Alet, Analía I. Colaboración en preparación de muestras biológicasÍtem Acceso Abierto Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology(Frontiers Research Foundation, 2018-05-01) D'Attilio, Luciano; Santucci, Natalia; Bongiovanni, Bettina; Bay, María Luisa; Bottasso, OscarÍtem Acceso Abierto Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy(S. Karger AG, 2018-09-25) González, Florencia Belén; Villar, Silvina Raquel; D'Attilio, Luciano; Leiva, Rodolfo; Marquez, Julia; Lioi, Susana; Beloscar, Juan; Bottasso, Oscar; Pérez, Ana RosaÍtem Acceso Abierto Hacia una concepción más abarcadora de la inflamación(Círculo Médico de Rosario, 2018) Bottasso, OscarÍtem Acceso Abierto Death of adrenocortical cells during murine acute T. cruzi infection is not associated with TNF-R1 signaling but mostly with the type II pathway of Fas-mediated apoptosis(Academic Press Inc Elsevier Science, 2017-10) Pérez, Ana Rosa; Lambertucci, Flavia; González, Florencia Belén; Roggero, Eduardo Angel; Bottasso, Oscar; de Meis, Juliana; Ronco, Maria Teresa; Villar, Silvina RaquelÍtem Acceso Abierto Características clínico-epidemiológicas de la estrongiloidiasis en pacientes portadores de co-morbilidades(Sociedad Chilena de Infectología, 2017-02) Regueira Fernandes, Amanda; Romero, Sebastián; Alcântara de Souza Melo, Paula Fernanda; Ramos Araújo, Paulo Sérgio; Bottasso, Oscar; Rocha, Abraham; Brandão, EduardoÍtem Acceso Abierto DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions(Elsevier) Cavatorta, Ana Laura; Di Gregorio, Alejandra; Bugnon Valdano, Marina Paula; Marziali, Federico Emanuel; Cabral, Mariela; Bottai, Hebe; Cittadini, Jorge; Nocito, Ana Lía; Gardiol, DanielaÍtem Acceso Abierto First evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviduct(Springer, 2014-02) Roldán, María Lorena; Marini, Patricia EstelaÍtem Embargo Recent applications of first- and second-order multivariate calibration to analytical chemistry(AOAC International, 2014-01) Arancibia, Juan Alberto; Damiani, Patricia Cecilia; Ibañez, Gabriela Alejandra; Olivieri, Alejandro CésarÍtem Acceso Abierto Mitogen-activated protein kinases are involved in hepatocanalicular dysfunction and cholestasis induced by oxidative stress(Springer, 2017-06) Toledo, Flavia D.; Basiglio, Cecilia Lorena; Barosso, Ismael R.; Boaglio, Andrea C.; Zucchetti, Andrés E.; Sanchez Pozzi, Enrique J.; Roma, Marcelo GabrielÍtem Acceso Abierto Antimicrobial and physicochemical characterization of whey protein concentrate edible films incorporated with liquid smoke.(Elsevier, 2016-10) Soazo, Marina del Valle; Pérez, Leonardo Martín; Piccirilli, Gisela Noemí; Delorenzi, Néstor Jorge; Verdini, Roxana Andrea