An experimental approach to study the red blood cell dynamics in a capillary tube by biospeckle laser
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Elsevier
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In this study we investigated the human red blood cell (RBC) dynamics by
means of biospeckle laser analysis. Blood samples from healthy donors were
introduced in a 0.8 mm internal diameter capillary tube, and illuminated with
a He-Ne laser in order to obtain the biospeckle pattern from both side and for-
ward scattered light. Experiments were carried out for di erent concentrations
of red blood cells in plasma, from 25% to 50%. Biospeckle parameters such as
Correlation Coe cient and Inertia Moment, were calculated for di erent fre-
quency bandwidths in order to assess their sensitivity and versatility. A lter
based on the Discrete Wavelet Transform was used to decompose the registered
sample activity. A relation between Inertia Moment and the RBCs to plasma
volume ratio was observed. The Correlation Index that measures the level of
correlation of biospeckle images was de ned and analyzed. This work inquires
in a technique that is suitable for the development of novel non-invasive optical
tools for clinical diagnosis in vascular pathologies.
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