Transcriptional and translational mechanisms contribute to regulate the expression of Disc Large 1 protein during different biological processes

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dc.citation.titleBiological Chemistryen
dc.citation.volume396(8)en
dc.contributor.other
dc.contributor.other
dc.contributor.other
dc.contributor.other
dc.contributor.other
dc.contributor.other
dc.creatorMarziali, Federico Emanuel
dc.creatorCavatorta, Ana Laura
dc.creatorBugnon Valdano, Marina Paula
dc.creatorFacciuto, Florencia Natalia
dc.creatorGardiol, Daniela
dc.date.accessioned2018-06-10T21:01:24Z
dc.date.available2018-06-10T21:01:24Z
dc.date.issued2015-03-14
dc.descriptionHuman discs large (DLG1) has been demonstrated to be involved in cell polarity and maintenance of tissue architecture. However, the mechanisms controlling DLG1 expression are not fully understood. This is relevant as DLG1 is lost during the later stages of malignant progression. We initiated a series of studies to analyse the mechanisms regulating DLG1 expression. We have previously reported the identification of an alternative splicing event in the 5′ untranslated region (5′ -UTR) of DLG1 mRNA that generates transcripts with two different 5′ -UTR (short and large 5′ -UTR variants). In this study, we further examined the impact of the DLG1 transcription and the role of the differential expression of the alternative 5′ -UTRs on DLG1 protein levels. We analysed these mechanisms during cell processes like differentiation, cell cycle progression and cell-cell contact formation, where the importance of DLG1 activities was previously established. The data presented in this report suggest that the transcriptional regulation of DLG1 strongly contributes to DLG1 abundance and that differential expression of alternative 5′ -UTRs with different translational properties, also cooperates, depending on the cell type and cell situation. This study provides new evidence for understanding the transcriptional regulation of DLG1 and the changes in DLG1 expression during different biological processeses
dc.description.filFil: Marziali, Federico Emanuel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Cavatorta, Ana Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Bugnon Valdano, Marina Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Facciuto, Florencia Natalia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Gardiol, Daniela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT), PICT 2008-0421es
dc.description.sponsorshipSecretaría de Ciencia, Tecnología e Innovación (Provincia de Santa Fe, Argentina)es
dc.formatapplication/pdf
dc.format.extent893-902en
dc.identifier.issn1437-4315
dc.identifier.urihttp://hdl.handle.net/2133/11431
dc.language.isoenges
dc.publisherDe Gruyteres
dc.relation.publisherversionhttps://www.degruyter.com/view/j/bchm.2015.396.issue-8/hsz-2014-0286/hsz-2014-0286.xmles
dc.relation.publisherversionhttp://dx.doi.org/10.1515/hsz-2014-0286es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderMarziali, Federico Emanueles
dc.rights.holderCavatorta, Ana Lauraes
dc.rights.holderBugnon Valdano, Marina Paulaes
dc.rights.holderFacciuto, Florencia Nataliaes
dc.rights.holderGardiol, Danielaes
dc.rights.holderDe Gruyteres
dc.rights.textAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.eses
dc.subject5´-UTRes
dc.subjectDLG1es
dc.subjectPolarityes
dc.subjectTranscription Regulationes
dc.subjectExpressiones
dc.titleTranscriptional and translational mechanisms contribute to regulate the expression of Disc Large 1 protein during different biological processeses

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