Longitudinal follow-up of the immunity to SARS-CoV-2 in health care workers in Argentina: Persistence of humoral response and neutralizing capacity after Sputnik V vaccination

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dc.citation.volume8
dc.creatorCastro, Eliana F.
dc.creatorAcosta, Julián
dc.creatorMoriena, Lucía
dc.creatorRios Medrano, Mayra
dc.creatorTejerina Cibello, Malena
dc.creatorCodino, Eduardo
dc.creatorTaborda, Miguel Ángel
dc.creatorÁlvarez, Diego E.
dc.creatorCavatorta, Ana Laura
dc.date.accessioned2023-08-10T18:28:26Z
dc.date.available2023-08-10T18:28:26Z
dc.date.issued2023-06-22
dc.descriptionSARS-CoV-2 vaccine protection has encountered waning of immune response and breakthrough infections. The hybrid immune response generated by the combination of vaccination and infection was shown to offer higher and broader protection. Here, we present a seroprevalence study of anti-SARS-CoV-2 spike/RBD IgG in 1,121 health care workers immunized with Sputnik V and a follow-up of humoral response at 2 and 24 weeks postvaccination (wpv), including neutralizing antibody response (NAT) against ancestral, Gamma, and Delta variants. The first seroprevalence study showed that among 122 individuals with one dose, 90.2% were seropositive versus 99.7% seropositivity among volunteers with the complete two-dose regimen. At 24 wpv, 98.7% of the volunteers remained seropositive, although antibody levels decreased. IgG levels and NAT were higher in individuals that had acquired COVID-19 previous to vaccination than in naive individuals at 2 and 24 wpv. Antibody levels dropped over time in both groups. In contrast, IgG levels and NAT increased after vaccine breakthrough infection. At 2 wpv, 35/40 naive individuals had detectable NAT against SARS-CoV-2 Gamma and 6/40 against Delta. In turn, 8/9 previously infected individuals developed a neutralizing response against SARS-CoV-2 Gamma and 4/9 against Delta variants. NAT against variants followed a trajectory similar to NAT against ancestral SARS-CoV-2, and breakthrough infection led to an increase in NAT and complete seroconversion against variants. In conclusion, Sputnik V-induced humoral response persisted at 6 months postvaccination, and hybrid immunity induced higher levels of anti-S/RBD antibodies and NAT in previously exposed individuals, boosted the response after vaccination, and conferred wider breadth of protection.es
dc.description.filFil: Castro, Eliana F. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Castro, Eliana F. Instituto Nacional de Tecnología Agropecuaria. Instituto de Virología e Innovaciones Tecnológicas. Centro de Investigaciones en Ciencias Veterinarias y Agronómicas; Argentina.
dc.description.filFil: Acosta, Julián. Instituto de Biología Molecular y Celular de Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Acosta, Julián. Universidad Nacional de Rosario .Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Moriena, Lucía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Tecnología en Salud Pública; Argentina.
dc.description.filFil: Rios Medrano, Mayra. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Tejerina Cibello, Malena. Universidad Nacional de San Martín, Buenos Aires. Escuela de Bio y Nanotecnologías; Argentina.
dc.description.filFil: Codino, Eduardo. Universidad Nacional de Rosario .Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Codino, Eduardo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Tecnología en Salud Pública; Argentina.
dc.description.filFil: Taborda, Miguel Ángel. Universidad Nacional de Rosario .Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Álvarez, Diego E. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Álvarez, Diego E. Universidad Nacional de San Martín, Buenos Aires. Escuela de Bio y Nanotecnologías; Argentina.
dc.description.filFil: Cavatorta, Ana Laura. Instituto de Biología Molecular y Celular de Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Cavatorta, Ana Laura. Universidad Nacional de Rosario .Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Cavatorta, Ana Laura.Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Tecnología en Salud Pública; Argentina.
dc.description.sponsorshipHospital Provincial del Centenario
dc.description.sponsorshipMinisterio de Salud de la Provincia de Santa Fe
dc.description.sponsorshipUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.description.sponsorshipArgentinean Research Agency-MINCYT: Covid Federal SF-10
dc.formatapplication/pdf
dc.identifier.issn2379-5042
dc.identifier.urihttp://hdl.handle.net/2133/26171
dc.language.isoenges
dc.publisherNLM (Medline)es
dc.relation.publisherversionhttps://doi.org/10.1128/msphere.00662-22es
dc.relation.publisherversionhttps://journals.asm.org/doi/10.1128/msphere.00662-22es
dc.rightsopenAccesses
dc.rights.holderCastro, Eliana F.es
dc.rights.holderAcosta, Juliánes
dc.rights.holderMoriena, Lucíaes
dc.rights.holderRios Medrano, Mayraes
dc.rights.holderTejerina Cibello, Malenaes
dc.rights.holderCodino, Eduardoes
dc.rights.holderTaborda, Miguel Ángeles
dc.rights.holderÁlvarez, Diego E.es
dc.rights.holderCavatorta, Ana Lauraes
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectHumoral immune responsees
dc.subjectHybrid immunityes
dc.subjectSARS-CoV-2es
dc.subjectSputnik Ves
dc.subjectVaccinationes
dc.titleLongitudinal follow-up of the immunity to SARS-CoV-2 in health care workers in Argentina: Persistence of humoral response and neutralizing capacity after Sputnik V vaccinationes
dc.typepublishedVersion
dc.typearticle
dc.typeartículo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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(FBIOyF) Departamento de Microbiología - Artículos
Colección Especial Coronavirus COVID-19