Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression

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dc.creatorDizanzo, María Paula
dc.creatorBugnon Valdano, Marina Paula
dc.creatorBasukala, Om
dc.creatorBanks, Lawrence
dc.creatorGardiol, Daniela
dc.date.accessioned2022-12-13T15:05:11Z
dc.date.available2022-12-13T15:05:11Z
dc.date.issued2022-12
dc.descriptionOncogenic Human Papillomaviruses (HPVs) base their transforming potential on the action of both E6 and E7 viral oncoproteins, which perform cooperative or antagonistic actions and thus interfere with a variety of relevant cellular targets. Among them, the expression of some PDZ-containing polarity proteins, as DLG1 and hScrib, is altered during the HPV life cycle and the consequent malignant transformation. Together with the well-established interference of E6 with PDZ proteins, we have recently shown that E7 viral oncoprotein is also responsible for the changes in abundance and localization of DLG1 observed in HPV-associated lesions. Given that the mechanisms involved remained only partially understood, we here thoroughly analyse the contribution of a crucial E7 post-translational modifcation: its CKII-dependent phosphorylation. Moreover, we extended our studies to hScrib, in order to investigate possible conserved regulatory events among diverse PDZ targets of HPV.es
dc.description.filFil: Dizanzo, María Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.
dc.description.filFil: Bugnon Valdano, Marina Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.
dc.description.filFil: Basukala,Om. International Centre for Genetic Engineering and Biotechnology. Tumour Virology Laboratory; Italy.
dc.description.filFil: Banks, Lawrence. International Centre for Genetic Engineering and Biotechnology. Tumour Virology Laboratory; Italy.
dc.description.filFil: Gardiol, Daniela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.
dc.description.sponsorshipAssociazione Italiana per la ricerca sul Cancro Grant number: IG 2019 23572
dc.formatapplication/pdf
dc.format.extent1-13
dc.identifier.issn1471-2407
dc.identifier.urihttp://hdl.handle.net/2133/25026
dc.language.isoenges
dc.publisherBMCes
dc.relation.publisherversionhttps://doi.org/10.1186/s12885-022-10105-5
dc.relation.publisherversionhttps://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-10105-5
dc.rightsopenAccesses
dc.rights.holderDizanzo, María Paulaes
dc.rights.holderBugnon Valdano, Marina Paulaes
dc.rights.holderBasukala,Omes
dc.rights.holderBanks, Lawrencees
dc.rights.holderGardiol, Danielaes
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHPV E7es
dc.subjectCKIIes
dc.subjectPDZes
dc.subjectDLG1 hScribes
dc.titleNovel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expressiones
dc.typeartículo
dc.typearticle
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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