Renal expression and urinary excretion of Na-K-2Cl cotransporter in obstructive nephropathy

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dc.citation.titleBioMed Research Internationales
dc.citation.volume2017es
dc.creatorBrandoni, Anabel
dc.creatorTorres, Adriana Mónica
dc.date.accessioned2021-02-24T20:20:03Z
dc.date.available2021-02-24T20:20:03Z
dc.date.issued2017-01-10
dc.descriptionRenal damage due to urinary tract obstruction accounts for up to 30% of acute kidney injury in paediatrics and adults. Bilateral ureteral obstruction (BUO) is associated with polyuria and reduced urinary concentrating capacity. We investigated the renal handling of water and electrolytes together with the renal expression and the urinary excretion of the Na-K-Cl cotransporter (NKCC2) after 1 (BUO-1), 2 (BUO-2), and 7 (BUO-7) days of release of BUO. Immunoblotting and immunohistochemical studies showed that NKCC2 expression was upregulated in apical membranes both from BUO-2 and from BUO-7 rats. The apical membrane expression, where NKCC2 is functional, may be sufficient to normalize water, potassium, sodium, and osmolytes tubular handling. NKCC2 abundance in homogenates and mRNA levels of NKCC2 was significantly decreased in almost all groups suggesting a decrease in the synthesis of the transporter. Urinary excretion of NKCC2 was increased in BUO-7 groups. These data suggest that the upregulation in the expression of NKCC2 in apical membranes during the postobstructive phase of BUO could contribute to improving the excretion of sodium and consequently also the excretion of potassium, osmolytes, and water. Moreover, the increase in urinary excretion of NKCC2 in BUO-7 group could be a potential additional biomarker of renal function recoveryes
dc.descriptionPara citar este articulo: Anabel Brandoni, Adriana M. Torres, "Renal Expression and Urinary Excretion of Na-K-2Cl Cotransporter in Obstructive Nephropathy", BioMed Research International, vol. 2017, Article ID 7171928, 9 pages, 2017. https://doi.org/10.1155/2017/7171928
dc.description.filFil: Brandoni, Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.es
dc.description.filFil: Brandoni, Anabel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Farmacología; Argentina.es
dc.description.filFil: Torres, Adriana Mónica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Farmacología; Argentina.es
dc.description.filFil: Torres, Adriana Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.es
dc.description.sponsorshipFondo para la Investigación Científica y Tecnológica (FONCYT): PICT 2012- No. 05-0225es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PIP 2012–2015, No. 00014es
dc.formatapplication/pdf
dc.format.extent1-9es
dc.identifier.issn2314-6141es
dc.identifier.urihttp://hdl.handle.net/2133/19909
dc.language.isoenges
dc.publisherHindawies
dc.relation.publisherversionhttps://doi.org/10.1155/2017/7171928es
dc.relation.publisherversionhttps://www.hindawi.com/journals/bmri/2017/7171928/es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderBrandoni, Anabeles
dc.rights.holderTorres, Adriana Mónicaes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectObstructive Nephropathyes
dc.subjectNa-K-2Cl Cotransporteres
dc.subjectUrinary Excretiones
dc.subjectRenal Expressiones
dc.subjectKidney Injuryes
dc.subjectBiomarkeres
dc.subjectRenal Function Recoveryes
dc.titleRenal expression and urinary excretion of Na-K-2Cl cotransporter in obstructive nephropathyes
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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