Renal expression and urinary excretion of Na-K-2Cl cotransporter in obstructive nephropathy
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Renal damage due to urinary tract obstruction accounts for up to 30% of acute kidney injury in paediatrics and adults. Bilateral
ureteral obstruction (BUO) is associated with polyuria and reduced urinary concentrating capacity. We investigated the renal
handling of water and electrolytes together with the renal expression and the urinary excretion of the Na-K-Cl cotransporter
(NKCC2) after 1 (BUO-1), 2 (BUO-2), and 7 (BUO-7) days of release of BUO. Immunoblotting and immunohistochemical studies
showed that NKCC2 expression was upregulated in apical membranes both from BUO-2 and from BUO-7 rats. The apical
membrane expression, where NKCC2 is functional, may be sufficient to normalize water, potassium, sodium, and osmolytes
tubular handling. NKCC2 abundance in homogenates and mRNA levels of NKCC2 was significantly decreased in almost all groups
suggesting a decrease in the synthesis of the transporter. Urinary excretion of NKCC2 was increased in BUO-7 groups. These data
suggest that the upregulation in the expression of NKCC2 in apical membranes during the postobstructive phase of BUO could
contribute to improving the excretion of sodium and consequently also the excretion of potassium, osmolytes, and water. Moreover,
the increase in urinary excretion of NKCC2 in BUO-7 group could be a potential additional biomarker of renal function recovery
Para citar este articulo: Anabel Brandoni, Adriana M. Torres, "Renal Expression and Urinary Excretion of Na-K-2Cl Cotransporter in Obstructive Nephropathy", BioMed Research International, vol. 2017, Article ID 7171928, 9 pages, 2017. https://doi.org/10.1155/2017/7171928
Para citar este articulo: Anabel Brandoni, Adriana M. Torres, "Renal Expression and Urinary Excretion of Na-K-2Cl Cotransporter in Obstructive Nephropathy", BioMed Research International, vol. 2017, Article ID 7171928, 9 pages, 2017. https://doi.org/10.1155/2017/7171928
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