Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity

Vista sencilla de ítem
dc.citation.titleMicrobial Cell
dc.citation.title4(4)
dc.creatorRodríguez Ayala, Facundo
dc.creatorBauman, Carlos
dc.creatorCogliati, Sebastián
dc.creatorLeñini, Cecilia
dc.creatorBartolini, Marco
dc.creatorGrau, Roberto Ricardo
dc.date.accessioned2021-03-11T19:28:42Z
dc.date.available2021-03-11T19:28:42Z
dc.date.issued2017-03-16
dc.descriptionProbiotics are live microorganisms that have beneficial effects on host health, including extended lifespan, when they are administered or present in adequate quantities. However, the mechanisms by which probiotics stimulate host longevity remain unclear and very poorly understood. In a recent study (Nat. Commun. 8, 14332 (2017) doi: 10.1038/ncomms14332), we used the spore-forming pro biotic bacterium Bacillus subtilis and the model organism Caenorhabditis elegans to study the mechanism by which a probiotic bacterium affects host longevity. We found that biofilm-proficient B. subtilis colonized the C. elegans gut and extended the worm lifespan significantly longer than did biofilm-deficient isogenic strains. In addition to biofilm proficiency, the quorum-sensing pentapeptide CSF and nitric oxide (NO) represent the entire B. subtilis rep ertoire responsible for the extended longevity of C. ele gans. B. subtilis grown under biofilm-supporting condi tions synthesized higher levels of NO and CSF than under planktonic growth conditions, emphasizing the key role of the biofilm in slowing host aging. Significantly, the pro longevity effect of B. subtilis was primarily due to a downregulation of the insulin-like signaling system that precisely is a key partaker in the healthy longevity of hu man centenarians. These findings open the possibility to test if the regular consumption of B. subtilis incorporated in foods and beverages could significantly extend human life expectancy and contribute to stop the development of age-related diseases.es
dc.description.filFil: Rodríguez Ayala, Facundo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Rodríguez Ayala, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Bauman, Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Bauman, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Cogliati, Sebastián. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Cogliati, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Leñini, Cecilia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Leñini, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Bartolini, Marco. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Bartolini, Marco. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Grau, Roberto Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Grau, Roberto Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)es
dc.description.sponsorshipFondo para la Investigación Científica y Tecnológica (FONCYT)es
dc.description.sponsorshipPew Latin-American Program in Biological Scienceses
dc.description.sponsorshipFulbright Committeees
dc.description.sponsorshipFundación Antorchases
dc.formatapplication/pdf
dc.format.extent133-136
dc.identifier.issn2311-2638
dc.identifier.urihttp://hdl.handle.net/2133/20128
dc.language.isoenges
dc.publisherShared Science Publisherses
dc.relation.publisherversionhttps://doi.org/10.15698/mic2017.04.569es
dc.relation.publisherversionhttp://microbialcell.com/researcharticles/microbial-flora-probiotics-bacillus-subtilis-and-the-search-for-a-long-and-healthy-human-longevity/es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderRodríguez Ayala, Facundoes
dc.rights.holderBauman, Carloses
dc.rights.holderCogliati, Sebastiánes
dc.rights.holderLeñini, Ceciliaes
dc.rights.holderBartolini, Marcoes
dc.rights.holderGrau, Roberto Ricardoes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectBacillus subtilises
dc.subjectProbioticses
dc.subjectBiofilmses
dc.subjectHealthy Longevityes
dc.subjectDiet Therapyes
dc.subjectInsulin Signalinges
dc.titleMicrobial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevityes
dc.typepublishedVersion

Archivos

Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
436.pdf
Tamaño:
792.02 KB
Formato:
Adobe Portable Document Format
Descripción:
versión post-print
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
Nombre:
license.txt
Tamaño:
3.59 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

(FBIOyF) Departamento de Microbiología - Artículos