DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions

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dc.citation.titleExperimental and Molecular Pathologyen
dc.citation.volume102 (1)
dc.creatorCavatorta, Ana Laura
dc.creatorDi Gregorio, Alejandra
dc.creatorBugnon Valdano, Marina Paula
dc.creatorMarziali, Federico Emanuel
dc.creatorCabral, Mariela
dc.creatorBottai, Hebe
dc.creatorCittadini, Jorge
dc.creatorNocito, Ana Lía
dc.creatorGardiol, Daniela
dc.date.accessioned2019-03-15T19:08:18Z
dc.date.available2019-03-15T19:08:18Z
dc.descriptionHuman Disc large tumor suppressor (DLG1) participates in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. However, it was demonstrated that DLG1 could acquire oncogenic attributes in some specific contexts. In this work, we evaluated the expression of DLG1 and its contribution to the progress of cervical lesions in order to investigate a potential role of this polarity protein in human oncogenic processes. We analyzed cervical biopsies from women with low-grade squamous intraepithelial lesion (LSIL) diagnosis (n=30), for DLG1 expression by immunohistochemistry. These results were correlated with the clinical monitoring of the patients during a 24-month follow-up period. Our data indicate that while all LSIL patients with a DLG1 staining pattern similar to normal tissues are significantly more likely to regress (n=23, Pattern I), all LSIL biopsy specimens showing a diffuse and intense DLG1 staining likely progress to high-grade lesions (n=4, Pattern II). Finally, all persistent LSIL analyzed showed an undetermined DLG1 staining, with a diffuse distribution without a strong intensity (n=3, Pattern III). We found a significant association between the expression pattern of DLG1 and the evolution of the lesion (p<0.00001). This work contributes to the knowledge of DLG1 biological functions, suggesting that its expression may have an important role in the progression of early dysplastic cervical lesions, giving prognostic information.es
dc.description.filFil: Cavatorta, Ana Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Di Gregorio, Alejandra. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Ginecología; Argentina.es
dc.description.filFil: Bugnon Valdano, Marina Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Marziali, Federico Emanuel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Cabral, Mariela. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Ginecología; Argentina.es
dc.description.filFil: Bottai, Hebe. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Estadística y Procesamiento de Datos; Argentina.es
dc.description.filFil: Cittadini, Jorge. Provincia de Santa Fe. Hospital Provincial del Centenario. Servicio de Ginecología; Argentina.es
dc.description.filFil: Nocito, Ana Lía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Cátedra de Anatomía y Fisiología Patológicas; Argentina.es
dc.description.filFil: Gardiol, Daniela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.sponsorshipInstituto Nacional del Cánceres
dc.description.sponsorshipMinisterio de Salud de la República Argentinaes
dc.description.sponsorshipProvincia de Santa Fe (Argentina)es
dc.formatapplication/pdf
dc.format.extent65-69
dc.identifier.issn0014-4800
dc.identifier.urihttp://hdl.handle.net/2133/14229
dc.language.isoenges
dc.publisherElsevier
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.yexmp.2016.12.008es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0014480016302623?via%3Dihub#ac0005es
dc.rightsopenAccesses
dc.rights.holderCavatorta, Ana Lauraes
dc.rights.holderDi Gregorio, Alejandraes
dc.rights.holderBugnon Valdano, Marina Paulaes
dc.rights.holderMarziali, Federico Emanueles
dc.rights.holderCabral, Marielaes
dc.rights.holderBottai, Hebees
dc.rights.holderCittadini, Jorgees
dc.rights.holderNocito, Ana Líaes
dc.rights.holderGardiol, Danielaes
dc.rights.holderElsevieres
dc.rights.holderAcademic Presses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.textAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es*
dc.subjectDLG1es
dc.subjectLSIL progressiones
dc.subjectImmunohistochemistryes
dc.subjectCervical canceres
dc.titleDLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesionses

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(FBIOyF) Departamento de Microbiología - Artículos
CIUNR - Ciencias Naturales - Artículos de Revista