Annexin A2 and S100A10 in the mammalian oviduct

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dc.citation.titleCell and Tissue Researches
dc.citation.volume363(2)es
dc.creatorTeijeiro, Juan Manuel
dc.creatorRoldán, María Lorena
dc.creatorMarini, Patricia Estela
dc.date.accessioned2017-11-22T19:17:36Z
dc.date.available2017-11-22T19:17:36Z
dc.date.issued2015-09
dc.descriptionIn many mammals, upon entry into the female reproductive tract, a subpopulation of sperm is stored in the oviduct forming a functional reservoir. In the oviducts of pig and cow, Annexin A2 (AnxA2) has been linked to the binding of sperm. This protein may exist as a monomer or bound to S100A10 and both forms are associated with different biological functions. S100A10 has not yet been reported in the oviduct. The objective of this work is to analyze for the presence of S100A10 in the oviduct and to advance the study of AnxA2 and S100A10 in this organ. This work shows the presence of both proteins, AnxA2 and S100A10, in the oviduct of human, pig, cow, cat, dog and rabbit. At least in pig, AnxA2 is found devoid of S100A10 in the outer surface of the apical plasma membrane of oviductal epithelial cells, indicating that it binds to sperm as a monomer or in association with proteins different from S100A10. In the apical cytoplasm of pig oviductal epithelial cells, AnxA2 is associated with S100A10. In primary culture of porcine oviductal cells, the expression of ANXA2 is increased by progesterone, while the expression of S100A10 is increased by progesterone and estradiol. The widespread detection of both proteins in the oviduct of mammals indicates a probable conserved function in this organ. In summary, S100A10 and AnxA2 are widespread in the mammalian oviduct but AnxA2 binds sperm in vivo devoid of S100A10 and may be related to reservoir formation.es
dc.description.filFil: Teijeiro, Juan Manuel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Medicina Reproductiva (UNR-CONICET); Argentinaes
dc.description.filFil: Roldán, María Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (UNR-CONICET); Argentinaes
dc.description.filFil: Marini, Patricia Estela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Medicina Reproductiva (UNR-CONICET); Argentinaes
dc.description.filFil: Marini, Patricia Estela. Universidad Nacional de Rosario. Consejo de Investigaciones; Argentinaes
dc.description.filFil: Marini, Patricia Estela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (UNR-CONICET); Argentinaes
dc.formatapplication/pdf
dc.format.extent567-77es
dc.identifier.issn0302-766Xes
dc.identifier.urihttp://hdl.handle.net/2133/9344
dc.language.isoenges
dc.publisherSpringer-Verlages
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs00441-015-2266-9es
dc.relation.publisherversionhttps://doi.org/10.1007/s00441-015-2266-9es
dc.rightsopenAccesses
dc.rights.holderSpringer-Verlag Berlin Heidelberges
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/*
dc.subjectAnexinaes
dc.subjectS100A10es
dc.subjectTrompas de Falopioes
dc.subjectReservorio de espermatozoideses
dc.subjectOviductoes
dc.titleAnnexin A2 and S100A10 in the mammalian oviductes
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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