Differential role of the T6SS in Acinetobacter baumannii virulence
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2015-09-24
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Public Library of Science (PLOS)
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Gram-negative bacteria, such as Acinetobacter baumannii, are an increasing burden in
hospitals worldwide with an alarming spread of multi-drug resistant (MDR) strains. Herein,
we compared a type strain (ATCC17978), a non-clinical isolate (DSM30011) and MDR
strains of A. baumannii implicated in hospital outbreaks (Ab242, Ab244 and Ab825), reveal ing distinct patterns of type VI secretion system (T6SS) functionality. The T6SS genomic
locus is present and was actively transcribed in all of the above strains. However, only the
A. baumannii DSM30011 strain was capable of killing Escherichia coli in a T6SS-dependent
manner, unlike the clinical isolates, which failed to display an active T6SS in vitro. In addi tion, DSM30011 was able to outcompete ATCC17978 as well as Pseudomonas aeruginosa
and Klebsiella pneumoniae, bacterial pathogens relevant in mixed nosocomial infections.
Finally, we found that the T6SS of DSM30011 is required for host colonization of the model
organism Galleria mellonella suggesting that this system could play an important role in A.
baumannii virulence in a strain-specific manner.
Para citar este articulo: Repizo GD, Gagné S, Foucault Grunenwald M-L, Borges V, Charpentier X, Limansky AS, et al. (2015) Differential Role of the T6SS in Acinetobacter baumannii Virulence. PLoS ONE 10(9): e0138265. doi:10.1371/journal.pone.0138265
Para citar este articulo: Repizo GD, Gagné S, Foucault Grunenwald M-L, Borges V, Charpentier X, Limansky AS, et al. (2015) Differential Role of the T6SS in Acinetobacter baumannii Virulence. PLoS ONE 10(9): e0138265. doi:10.1371/journal.pone.0138265
Palabras clave
Acinetobacter baumannii, Virulence, T6SS