Differential role of the T6SS in Acinetobacter baumannii virulence

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dc.citation.titlePLoS ONE
dc.citation.title10(9)
dc.creatorRepizo, Guillermo Daniel
dc.creatorGagné, Stéphanie
dc.creatorFoucault-Grunenwald, Marie-Laure
dc.creatorBorges, Vitor
dc.creatorCharpentier, Xavier
dc.creatorLimansky, Adriana S.
dc.creatorGomes, João Paulo
dc.creatorViale, Alejandro M.
dc.creatorSalcedo, Suzana P.
dc.date.accessioned2021-03-18T22:27:04Z
dc.date.available2021-03-18T22:27:04Z
dc.date.issued2015-09-24
dc.descriptionGram-negative bacteria, such as Acinetobacter baumannii, are an increasing burden in hospitals worldwide with an alarming spread of multi-drug resistant (MDR) strains. Herein, we compared a type strain (ATCC17978), a non-clinical isolate (DSM30011) and MDR strains of A. baumannii implicated in hospital outbreaks (Ab242, Ab244 and Ab825), reveal ing distinct patterns of type VI secretion system (T6SS) functionality. The T6SS genomic locus is present and was actively transcribed in all of the above strains. However, only the A. baumannii DSM30011 strain was capable of killing Escherichia coli in a T6SS-dependent manner, unlike the clinical isolates, which failed to display an active T6SS in vitro. In addi tion, DSM30011 was able to outcompete ATCC17978 as well as Pseudomonas aeruginosa and Klebsiella pneumoniae, bacterial pathogens relevant in mixed nosocomial infections. Finally, we found that the T6SS of DSM30011 is required for host colonization of the model organism Galleria mellonella suggesting that this system could play an important role in A. baumannii virulence in a strain-specific manner.es
dc.descriptionPara citar este articulo: Repizo GD, Gagné S, Foucault Grunenwald M-L, Borges V, Charpentier X, Limansky AS, et al. (2015) Differential Role of the T6SS in Acinetobacter baumannii Virulence. PLoS ONE 10(9): e0138265. doi:10.1371/journal.pone.0138265
dc.description.filFil: Repizo, Guillermo Daniel. Université Lyon – Centre national de la recherche scientifique (CNRS). Bases Moléculaires et Structurales des Systèmes Infectieux; France.
dc.description.filFil: Repizo, Guillermo Daniel. Université Lyon – Centre national de la recherche scientifique (CNRS). Institut de Biologie et Chimie des Protéines; France.
dc.description.filFil: Gagné, Stéphanie. Université Lyon – Centre national de la recherche scientifique (CNRS). Bases Moléculaires et Structurales des Systèmes Infectieux; France.
dc.description.filFil: Gagné, Stéphanie. Université Lyon – Centre national de la recherche scientifique (CNRS). Bases Moléculaires et Structurales des Systèmes Infectieux; France.
dc.description.filFil: Foucault-Grunenwald, Marie-Laure. Université Lyon – Centre national de la recherche scientifique (CNRS). Unité de Microbiologie, Adaptation et Pathogénie; France.
dc.description.filFil: Foucault-Grunenwald, Marie-Laure. Université Lyon – Centre national de la recherche scientifique (CNRS). Unité de Microbiologie, Adaptation et Pathogénie; France.
dc.description.filFil: Borges, Vitor. National Institute of Health. Department of Infectious Diseases. Bioinformatics Unit; Portugal.
dc.description.filFil: Charpentier, Xavier. Université Lyon – Centre national de la recherche scientifique (CNRS). Unité de Microbiologie, Adaptation et Pathogénie; France.
dc.description.filFil: Limansky, Adriana S. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.
dc.description.filFil: Limansky, Adriana S. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Gomes, João Paulo. National Institute of Health. Department of Infectious Diseases. Bioinformatics Unit; Portugal.
dc.description.filFil: Viale, Alejandro M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.
dc.description.filFil: Viale, Alejandro M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Salcedo, Suzana P. Université Lyon – Centre national de la recherche scientifique (CNRS). Bases Moléculaires et Structurales des Systèmes Infectieux; France.
dc.description.filFil: Salcedo, Suzana P. Université Lyon – Centre national de la recherche scientifique (CNRS). Institut de Biologie et Chimie des Protéines; France.
dc.description.sponsorshipFINOVI Young Researcher Grantes
dc.description.sponsorshipInstitut National de la Santé et de la Recherche Médicale (INSERM)es
dc.description.sponsorshipCNRS-Inserm ATIP-Avenir Programes
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)es
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT)es
dc.description.sponsorshipSecretaría de Ciencia, Tecnología e Innovación de la provincia de Santa Fees
dc.formatapplication/pdf
dc.format.extent1-20
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/2133/20230
dc.language.isoenges
dc.publisherPublic Library of Science (PLOS)es
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0138265es
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138265es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderRepizo, Guillermo Danieles
dc.rights.holderGagné, Stéphaniees
dc.rights.holderFoucault-Grunenwald, Marie-Laurees
dc.rights.holderBorges, Vitores
dc.rights.holderCharpentier, Xavieres
dc.rights.holderLimansky, Adriana S.es
dc.rights.holderGomes, João Pauloes
dc.rights.holderViale, Alejandro M.es
dc.rights.holderSalcedo, Suzana P.es
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAcinetobacter baumanniies
dc.subjectVirulencees
dc.subjectT6SSes
dc.titleDifferential role of the T6SS in Acinetobacter baumannii virulencees
dc.typepublishedVersion

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