Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity

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dc.contributor.author Rozados, Viviana R.
dc.contributor.author Sánchez, Andrea M.
dc.contributor.author Gervasoni, Silvia I.
dc.contributor.author Berra, Héctor H.
dc.contributor.author Matar, Pablo
dc.contributor.author Scharovsky, O. Graciela
dc.date.accessioned 2012-08-28T18:23:35Z
dc.date.available 2012-08-28T18:23:35Z
dc.date.issued 2004-10
dc.identifier.citation Rozados, V. R., Sánchez, A. M., Gervasoni, S. I., Berra, H. H., Matar, P., & Graciela, S. O. (2004). Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity. Annals of Oncology, 15, 10, 1543-1550. es
dc.identifier.issn 0923-7534
dc.identifier.uri http://hdl.handle.net/2133/2013
dc.description.abstract BACKGROUND: Our aim was to investigate the clinical efficacy and toxicity of metronomic administration of low-dose cyclophosphamide (Cy) in lymphoma and sarcoma rat tumour models. METHODS: Adult inbred rats were challenged with lymphoma TACB and sarcoma E100 s.c. on day 0. Animals were divided into two groups: group I, control, injected with saline three times a week; and group II, treated with Cy 10 mg/kg three times a week, from day 10 until the tumour was non-palpable, or 5 mg/kg three times a week from day 7. Tumours were measured and animals were weighed twice weekly. Periodic blood samples were taken for determination of urea, creatinine, serum glutamic-oxaloacetic transaminase, lactate dehydrogenase and haematological parameters. RESULTS: The administration of low-dose Cy eradicated established rat lymphomas and sarcomas; there was neither metastatic growth nor recurrence at primary sites for 100% of the lymphomas and 83% of the sarcomas. In addition, the treatment did not cause weight loss, and was devoid of haematological, cardiac, hepatic and renal toxicity. CONCLUSIONS: Metronomic administration of Cy at low doses on a thrice weekly schedule to already grown rat lymphomas and sarcomas demonstrated itself to be a successful antitumour therapy that did not cause weight loss and was devoid of haematological, cardiac, hepatic and renal toxicity. es
dc.format application/pdf
dc.language.iso en es
dc.publisher Oxford University Press es
dc.rights openAccess
dc.subject Cyclophosphamide es
dc.subject Lymphoma es
dc.subject Metronomic dosing es
dc.subject Sarcoma es
dc.subject Toxicity es
dc.title Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity es
dc.type artículo
dc.type publishedVersion
dc.type article
dc.description.peerreviewed Peer reviewed es
dc.relation.publisherversion http://dx.doi.org/10.1093/annonc/mdh384 es
dc.rights.text © European Society for Medical Oncology es


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