Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity

dc.contributor.authorRozados, Viviana R.
dc.contributor.authorSánchez, Andrea M.
dc.contributor.authorGervasoni, Silvia I.
dc.contributor.authorBerra, Héctor H.
dc.contributor.authorMatar, Pablo
dc.contributor.authorScharovsky, O. Graciela
dc.date.accessioned2012-08-28T18:23:35Z
dc.date.available2012-08-28T18:23:35Z
dc.date.issued2004-10
dc.description.abstractBACKGROUND: Our aim was to investigate the clinical efficacy and toxicity of metronomic administration of low-dose cyclophosphamide (Cy) in lymphoma and sarcoma rat tumour models. METHODS: Adult inbred rats were challenged with lymphoma TACB and sarcoma E100 s.c. on day 0. Animals were divided into two groups: group I, control, injected with saline three times a week; and group II, treated with Cy 10 mg/kg three times a week, from day 10 until the tumour was non-palpable, or 5 mg/kg three times a week from day 7. Tumours were measured and animals were weighed twice weekly. Periodic blood samples were taken for determination of urea, creatinine, serum glutamic-oxaloacetic transaminase, lactate dehydrogenase and haematological parameters. RESULTS: The administration of low-dose Cy eradicated established rat lymphomas and sarcomas; there was neither metastatic growth nor recurrence at primary sites for 100% of the lymphomas and 83% of the sarcomas. In addition, the treatment did not cause weight loss, and was devoid of haematological, cardiac, hepatic and renal toxicity. CONCLUSIONS: Metronomic administration of Cy at low doses on a thrice weekly schedule to already grown rat lymphomas and sarcomas demonstrated itself to be a successful antitumour therapy that did not cause weight loss and was devoid of haematological, cardiac, hepatic and renal toxicity.es
dc.description.peerreviewedPeer reviewedes
dc.formatapplication/pdf
dc.identifier.citationRozados, V. R., Sánchez, A. M., Gervasoni, S. I., Berra, H. H., Matar, P., & Graciela, S. O. (2004). Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity. Annals of Oncology, 15, 10, 1543-1550.es
dc.identifier.issn0923-7534
dc.identifier.urihttp://hdl.handle.net/2133/2013
dc.language.isoenes
dc.publisherOxford University Presses
dc.relation.publisherversionhttp://dx.doi.org/10.1093/annonc/mdh384es
dc.rightsopenAccess
dc.rights.text© European Society for Medical Oncologyes
dc.subjectCyclophosphamidees
dc.subjectLymphomaes
dc.subjectMetronomic dosinges
dc.subjectSarcomaes
dc.subjectToxicityes
dc.titleMetronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicityes
dc.typeartículo
dc.typepublishedVersion
dc.typearticle

Archivos

Bloque original
Mostrando 1 - 1 de 1
Cargando...
Miniatura
Nombre:
Paper Ann Oncol 2004.pdf
Tamaño:
136.72 KB
Formato:
Adobe Portable Document Format
Bloque de licencias
Mostrando 1 - 1 de 1
Nombre:
license.txt
Tamaño:
0 B
Formato:
Item-specific license agreed upon to submission
Descripción: