The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen

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dc.creator Repizo, Guillermo Daniel
dc.creator Viale, Alejandro M.
dc.creator Borges, Vítor
dc.creator Cameranesi, María Marcela
dc.creator Taib, Najwa
dc.creator Espariz, Martín
dc.creator Brochier-Armanet, Céline
dc.creator Gomes, João Paulo
dc.creator Salcedo, Suzana P.
dc.date.accessioned 2021-03-11T18:10:25Z
dc.date.available 2021-03-11T18:10:25Z
dc.date.issued 2017-08-26
dc.identifier.issn 1759-6653
dc.identifier.uri http://hdl.handle.net/2133/20126
dc.description Acinetobacter baumannii represents nowadays an important nosocomial opportunistic pathogen whose reservoirs outside the clinical setting are obscure. Here, we traced the origins of the collection strain A. baumannii DSM30011 to an isolate first reported in 1944, obtained from the enriched microbiota responsible of the aerobic decomposition of the resinous desert shrub guayule. Whole-genome sequencing and phylogenetic analysis based on core genes confirmed DSM30011 affiliation to A. baumannii. Comparative studies with 32 complete A. baumannii genomes revealed the presence of 12 unique accessory chromosomal regions in DSM30011 including five encompassing phage-related genes, five containing toxin genes of the type-6 secretion system, and one with an atypical CRISPRs/cas cluster. No antimicrobial resistance islands were identified in DSM30011 agreeingwithageneralantimicrobialsusceptibilityphenotypeincludingfolatesynthesisinhibitors.Themarginalampicillinresistance of DSM30011 most likely derived from chromosomal ADC-type ampC and blaOXA-51-type genes. Searching for catabolic pathways genes revealed several clusters involved in the degradation of plant defenses including woody tissues and a previously unreported atu locus responsible of aliphatic terpenes degradation, thus suggesting that resinous plants may provide an effective niche for this organism. DSM30011 also harbored most genes and regulatory mechanisms linked to persistence and virulence in pathogenicAcinetobacterspecies. This strain thus revealed important clues into the genomic diversity, virulence potential, and niche ranges of the preantibiotic era A. baumannii population, and may provide an useful tool for our understanding of the processes that led to the recent evolution of this species toward an opportunistic pathogen of humans. es
dc.description This article has been accepted for publication in Genome Biology and Evolution Published by Oxford University Press.
dc.description.sponsorship FINOVI Young Researcher Grant es
dc.description.sponsorship Investissement d’Avenir: ANR-10-BINF-01-01 es
dc.description.sponsorship Agencia Nacional de Promocion Científica y Tecnológica (ANPCyT) es
dc.description.sponsorship Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PIP1055 es
dc.description.sponsorship Ministerio de Ciencia, Tecnología e Innovación Productiva (MINCTIP) es
dc.format application/pdf
dc.format.extent 2292–2307
dc.language.iso eng es
dc.publisher Oxford University Press es
dc.rights openAccess es
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/ *
dc.subject Comparative Genomics es
dc.subject Pre-antibiotic Era es
dc.subject Virulence Factors es
dc.subject CRISPR-cas es
dc.title The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen es
dc.type publishedVersion
dc.rights.holder Universidad Nacional de Rosario es
dc.rights.holder Repizo, Guillermo Daniel es
dc.rights.holder Viale, Alejandro M. es
dc.rights.holder Borges, Vítor es
dc.rights.holder Cameranesi, María Marcela es
dc.rights.holder Taib, Najwa es
dc.rights.holder Espariz, Martín es
dc.rights.holder Brochier-Armanet, Céline es
dc.rights.holder Gomes, João Paulo es
dc.rights.holder Salcedo, Suzana P. es
dc.relation.publisherversion https://doi.org/10.1093/gbe/evx162 es
dc.relation.publisherversion https://academic.oup.com/gbe/article/9/9/2292/4095374 es
dc.rights.text Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) es
dc.citation.title Genome Biology and Evolution
dc.citation.volume 9(9)
dc.description.fil Fil: Repizo, Guillermo Daniel. University of Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratory of Molecular Microbiology and Structural Biochemistry; France.
dc.description.fil Fil: Repizo, Guillermo Daniel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.fil Fil: Repizo, Guillermo Daniel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil Fil: Viale, Alejandro M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.fil Fil: Viale, Alejandro M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil Fil: Borges, Vítor. National Institute of Health. Department of Infectious Diseases. Bioinformatics Unit; Portugal.
dc.description.fil Fil: Cameranesi, María Marcela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.fil Fil: Cameranesi, María Marcela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil Fil: Taib, Najwa. Université Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratoire de Biométrie et Biologie Évolutive; France.
dc.description.fil Fil: Espariz, Martín. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.fil Fil: Espariz, Martín. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil Fil: Brochier-Armanet, Céline. Université Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratoire de Biométrie et Biologie Évolutive; France.
dc.description.fil Fil: Gomes, João Paulo. National Institute of Health. Department of Infectious Diseases. Bioinformatics Unit; Portugal.
dc.description.fil Fil: Salcedo, Suzana P. University of Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratory of Molecular Microbiology and Structural Biochemistry; France.


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