The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen

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dc.creator	Repizo, Guillermo Daniel
dc.creator	Viale, Alejandro M.
dc.creator	Borges, Vítor
dc.creator	Cameranesi, María Marcela
dc.creator	Taib, Najwa
dc.creator	Espariz, Martín
dc.creator	Brochier-Armanet, Céline
dc.creator	Gomes, João Paulo
dc.creator	Salcedo, Suzana P.
dc.date.accessioned	2021-03-11T18:10:25Z
dc.date.available	2021-03-11T18:10:25Z
dc.date.issued	2017-08-26
dc.identifier.issn	1759-6653
dc.identifier.uri	http://hdl.handle.net/2133/20126
dc.description	Acinetobacter baumannii represents nowadays an important nosocomial opportunistic pathogen whose reservoirs outside the clinical setting are obscure. Here, we traced the origins of the collection strain A. baumannii DSM30011 to an isolate first reported in 1944, obtained from the enriched microbiota responsible of the aerobic decomposition of the resinous desert shrub guayule. Whole-genome sequencing and phylogenetic analysis based on core genes confirmed DSM30011 affiliation to A. baumannii. Comparative studies with 32 complete A. baumannii genomes revealed the presence of 12 unique accessory chromosomal regions in DSM30011 including five encompassing phage-related genes, five containing toxin genes of the type-6 secretion system, and one with an atypical CRISPRs/cas cluster. No antimicrobial resistance islands were identified in DSM30011 agreeingwithageneralantimicrobialsusceptibilityphenotypeincludingfolatesynthesisinhibitors.Themarginalampicillinresistance of DSM30011 most likely derived from chromosomal ADC-type ampC and blaOXA-51-type genes. Searching for catabolic pathways genes revealed several clusters involved in the degradation of plant defenses including woody tissues and a previously unreported atu locus responsible of aliphatic terpenes degradation, thus suggesting that resinous plants may provide an effective niche for this organism. DSM30011 also harbored most genes and regulatory mechanisms linked to persistence and virulence in pathogenicAcinetobacterspecies. This strain thus revealed important clues into the genomic diversity, virulence potential, and niche ranges of the preantibiotic era A. baumannii population, and may provide an useful tool for our understanding of the processes that led to the recent evolution of this species toward an opportunistic pathogen of humans.	es
dc.description	This article has been accepted for publication in Genome Biology and Evolution Published by Oxford University Press.
dc.description.sponsorship	FINOVI Young Researcher Grant	es
dc.description.sponsorship	Investissement d’Avenir: ANR-10-BINF-01-01	es
dc.description.sponsorship	Agencia Nacional de Promocion Científica y Tecnológica (ANPCyT)	es
dc.description.sponsorship	Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PIP1055	es
dc.description.sponsorship	Ministerio de Ciencia, Tecnología e Innovación Productiva (MINCTIP)	es
dc.format	application/pdf
dc.format.extent	2292–2307
dc.language.iso	eng	es
dc.publisher	Oxford University Press	es
dc.rights	openAccess	es
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject	Comparative Genomics	es
dc.subject	Pre-antibiotic Era	es
dc.subject	Virulence Factors	es
dc.subject	CRISPR-cas	es
dc.title	The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen	es
dc.type	publishedVersion
dc.rights.holder	Universidad Nacional de Rosario	es
dc.rights.holder	Repizo, Guillermo Daniel	es
dc.rights.holder	Viale, Alejandro M.	es
dc.rights.holder	Borges, Vítor	es
dc.rights.holder	Cameranesi, María Marcela	es
dc.rights.holder	Taib, Najwa	es
dc.rights.holder	Espariz, Martín	es
dc.rights.holder	Brochier-Armanet, Céline	es
dc.rights.holder	Gomes, João Paulo	es
dc.rights.holder	Salcedo, Suzana P.	es
dc.relation.publisherversion	https://doi.org/10.1093/gbe/evx162	es
dc.relation.publisherversion	https://academic.oup.com/gbe/article/9/9/2292/4095374	es
dc.rights.text	Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)	es
dc.citation.title	Genome Biology and Evolution
dc.citation.volume	9(9)
dc.description.fil	Fil: Repizo, Guillermo Daniel. University of Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratory of Molecular Microbiology and Structural Biochemistry; France.
dc.description.fil	Fil: Repizo, Guillermo Daniel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.fil	Fil: Repizo, Guillermo Daniel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil	Fil: Viale, Alejandro M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.fil	Fil: Viale, Alejandro M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil	Fil: Borges, Vítor. National Institute of Health. Department of Infectious Diseases. Bioinformatics Unit; Portugal.
dc.description.fil	Fil: Cameranesi, María Marcela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.fil	Fil: Cameranesi, María Marcela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil	Fil: Taib, Najwa. Université Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratoire de Biométrie et Biologie Évolutive; France.
dc.description.fil	Fil: Espariz, Martín. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.fil	Fil: Espariz, Martín. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.fil	Fil: Brochier-Armanet, Céline. Université Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratoire de Biométrie et Biologie Évolutive; France.
dc.description.fil	Fil: Gomes, João Paulo. National Institute of Health. Department of Infectious Diseases. Bioinformatics Unit; Portugal.
dc.description.fil	Fil: Salcedo, Suzana P. University of Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratory of Molecular Microbiology and Structural Biochemistry; France.