The environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogen

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dc.citation.titleGenome Biology and Evolution
dc.citation.volume9(9)
dc.creatorRepizo, Guillermo Daniel
dc.creatorViale, Alejandro M.
dc.creatorBorges, Vítor
dc.creatorCameranesi, María Marcela
dc.creatorTaib, Najwa
dc.creatorEspariz, Martín
dc.creatorBrochier-Armanet, Céline
dc.creatorGomes, João Paulo
dc.creatorSalcedo, Suzana P.
dc.date.accessioned2021-03-11T18:10:25Z
dc.date.available2021-03-11T18:10:25Z
dc.date.issued2017-08-26
dc.descriptionAcinetobacter baumannii represents nowadays an important nosocomial opportunistic pathogen whose reservoirs outside the clinical setting are obscure. Here, we traced the origins of the collection strain A. baumannii DSM30011 to an isolate first reported in 1944, obtained from the enriched microbiota responsible of the aerobic decomposition of the resinous desert shrub guayule. Whole-genome sequencing and phylogenetic analysis based on core genes confirmed DSM30011 affiliation to A. baumannii. Comparative studies with 32 complete A. baumannii genomes revealed the presence of 12 unique accessory chromosomal regions in DSM30011 including five encompassing phage-related genes, five containing toxin genes of the type-6 secretion system, and one with an atypical CRISPRs/cas cluster. No antimicrobial resistance islands were identified in DSM30011 agreeingwithageneralantimicrobialsusceptibilityphenotypeincludingfolatesynthesisinhibitors.Themarginalampicillinresistance of DSM30011 most likely derived from chromosomal ADC-type ampC and blaOXA-51-type genes. Searching for catabolic pathways genes revealed several clusters involved in the degradation of plant defenses including woody tissues and a previously unreported atu locus responsible of aliphatic terpenes degradation, thus suggesting that resinous plants may provide an effective niche for this organism. DSM30011 also harbored most genes and regulatory mechanisms linked to persistence and virulence in pathogenicAcinetobacterspecies. This strain thus revealed important clues into the genomic diversity, virulence potential, and niche ranges of the preantibiotic era A. baumannii population, and may provide an useful tool for our understanding of the processes that led to the recent evolution of this species toward an opportunistic pathogen of humans.es
dc.descriptionThis article has been accepted for publication in Genome Biology and Evolution Published by Oxford University Press.
dc.description.filFil: Repizo, Guillermo Daniel. University of Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratory of Molecular Microbiology and Structural Biochemistry; France.
dc.description.filFil: Repizo, Guillermo Daniel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.filFil: Repizo, Guillermo Daniel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Viale, Alejandro M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.filFil: Viale, Alejandro M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Borges, Vítor. National Institute of Health. Department of Infectious Diseases. Bioinformatics Unit; Portugal.
dc.description.filFil: Cameranesi, María Marcela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.filFil: Cameranesi, María Marcela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Taib, Najwa. Université Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratoire de Biométrie et Biologie Évolutive; France.
dc.description.filFil: Espariz, Martín. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR - CONICET); Argentina.
dc.description.filFil: Espariz, Martín. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Brochier-Armanet, Céline. Université Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratoire de Biométrie et Biologie Évolutive; France.
dc.description.filFil: Gomes, João Paulo. National Institute of Health. Department of Infectious Diseases. Bioinformatics Unit; Portugal.
dc.description.filFil: Salcedo, Suzana P. University of Lyon - Centre National de la Recherche Scientifique (CNRS). Laboratory of Molecular Microbiology and Structural Biochemistry; France.
dc.description.sponsorshipFINOVI Young Researcher Grantes
dc.description.sponsorshipInvestissement d’Avenir: ANR-10-BINF-01-01es
dc.description.sponsorshipAgencia Nacional de Promocion Científica y Tecnológica (ANPCyT)es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PIP1055es
dc.description.sponsorshipMinisterio de Ciencia, Tecnología e Innovación Productiva (MINCTIP)es
dc.formatapplication/pdf
dc.format.extent2292–2307
dc.identifier.issn1759-6653
dc.identifier.urihttp://hdl.handle.net/2133/20126
dc.language.isoenges
dc.publisherOxford University Presses
dc.relation.publisherversionhttps://doi.org/10.1093/gbe/evx162es
dc.relation.publisherversionhttps://academic.oup.com/gbe/article/9/9/2292/4095374es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderRepizo, Guillermo Danieles
dc.rights.holderViale, Alejandro M.es
dc.rights.holderBorges, Vítores
dc.rights.holderCameranesi, María Marcelaes
dc.rights.holderTaib, Najwaes
dc.rights.holderEspariz, Martínes
dc.rights.holderBrochier-Armanet, Célinees
dc.rights.holderGomes, João Pauloes
dc.rights.holderSalcedo, Suzana P.es
dc.rights.textAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectComparative Genomicses
dc.subjectPre-antibiotic Eraes
dc.subjectVirulence Factorses
dc.subjectCRISPR-cases
dc.titleThe environmental Acinetobacter baumannii isolate DSM30011 reveals clues into the preantibiotic era genome diversity, virulence potential, and niche range of a predominant nosocomial pathogenes
dc.typepublishedVersion

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