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Ítem Acceso Abierto Preformulation and long-term stability studies of an optimized palatable praziquantel Ethanol-free Solution for pediatric delivery(MDPI, 30-07-23) Bedogni, Giselle; García, Paula; Seremeta, Katia; Okulik, Nora; Salomon, Claudio; https://orcid.org/0000-0001-6302-7073To date, the treatment for cysticercosis and neurocysticercosis consists of a single oral intake of praziquantel (5–10 mg/kg), which since it is only available as tablets, hinders its administration to pediatric patients. Praziquantel is a poorly water-soluble drug which represents a challenge for its formulation in solution, particularly for the pediatric population. Thus, this study aimed to develop a palatable solution for praziquantel using pharmaceutical-accepted co-solvent systems. A design of experiments approach was applied to identify the optimal conditions for achieving a suitable amount of praziquantel in solution using co-solvent mixtures. Thus, praziquantel solubility increased from 0.38 up to 43.50 mg/mL in the optimized system. A taste masking assay in healthy human volunteers confirmed a successful reduction of drug bitterness after the addition of selected flavors and a sweetener. Stability studies were also conducted at different temperatures (4, 25, and 40 °C) for 12 months Even though the presence of the three known impurities of praziquantel was observed, their amounts never exceeded the acceptance criteria of the USP. Thus, this novel approach should be considered a valuable alternative for further preclinical studies considering the high prevalence of this infection worldwide.Ítem Acceso Abierto Bol CIM 200 : Anticuerpos monoclonales(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2012-07) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Bol CIM 201 : Uso del sildenafil en pediatría(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2012-09) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Bol CIM 202 : Cepas recomendadas para las vacunas antigripales temporada 2013 : Protección contra la radiación solar(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2012-11) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Seguridad del paciente : aplicación de gestión de calidad para prevenir errores de medicación en el circuito de uso de medicamentos(Elsevier España (Elsevier Doyma), 2013) Salamano, Mercedes; Palchik, Valeria; Botta, Carina; Colautti, Marisel; Bianchi, Mariela; Traverso, María LuzÍtem Acceso Abierto Organic anion transporter 5 renal expression and urinary excretion in rats with vascular calcification(Wiley, 2013) Hazelhoff, María Herminia; Bulacio, Romina Paula; Torres, Adriana MónicaIt has been described renal damage in rats with vascular calcification. The organic anion transporter 5 (Oat5) is only expressed in kidney, and its urinary excretion was proposed as potential early biomarker of renal injury. The aim of this study was to evaluate the Oat5 renal expression and its urinary excretion in an experimental model of vascular calcification in comparison with traditional markers of renal injury. Vascular calcification was obtained by the administration of an overdose of vitamin D3 (300,000 IU/kg, b.w., i.m.) to male Wistar rats. Oat5 urinary abundance was evaluated by Western blotting. Traditional markers of renal injury, such as creatinine and urea plasma levels, urinary protein levels, and urinary alkaline phosphatase (AP) activity, were determined using commercial kits. Histology was assessed by hematoxylin/eosin staining. Oat5 renal expression was evaluated by Western blotting and by immunohistochemistry. An increased expression of Oat5 in renal homogenates, in apical membranes, and in its urinary excretion was observed in rats with vascular calcification. The traditional parameters used to evaluate renal function were not modified, with the exception of histology. It is possible to postulate the urinary excretion of Oat5 as a potential noninvasive biomarker of renal injury associated with vascular calcification.Ítem Acceso Abierto Bol CIM 203 : Seguridad de benzodiacepinas(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2013-01) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Análisis de la prescripción de medicamentos en una comunidad geriátrica Argentina(Sociedad Médica de Santiago, 2013-02) Marzi, Marta Mónica; Diruscio, Valeriana Alejandra; Núñez, Mariano H.; Pires, Miryam Susana; Quaglia, Nora BeatrízBackground: Although polypharmacy may bejustified in elderly patients with multiple diseases, it may be dangerous, especially when it includes potentially inappropriate medications (PIM). Aim: To identify inappropriate medication and factors associated with the most relevant prescriptions among older people. Material and Methods: Cross-sectional observational analysis of drugs prescribed during the first trimester of 2010 to 179 older adults aged 77 ± 8 years (98 women), living in a geriatric reference hospital in Argentina. The use of potentially inappropriate medications (PIM) in elderly patients was analyzed using Beers Criteria updated to 2012. Results: The mean number of drugs prescribed per individual was 6.1 ± 2.7. The most commonly used drugs were anti-ulcer agents (58.1%), agents acting on the renin-angiotensin system (54.2%), antithrombotic medications (50.8%) and benzodiazepines (50.8 %). The use of antacids and anti-ulcer agents, psychotropic drugs and PIM was significantly higher among patients using six or more drugs daily, compared to the less medicated group (odds ratio (OR) = 6.8, 95% confidence intervals (CI) 3.5-13.2; OR=15.0, 95%CI 5.9-38.4; OR=5.0; 95%IC 2.6-9.8, respectively). Thirty one percent of participants using non-steroidal anti-inflammatory drugs, were not receiving medications for gastric protection. One to four drugs included in the Beers list were prescribed to 66% of participants. Conclusions: Despite the high prevalence of use of antacids and anti-ulcer agents, these drugs were not prescribed to a significant proportion of patients using non-steroidal anti-inflammatory drugs. Strategies to optimize pharmacotherapy in the elderly population are urgently required.Ítem Acceso Abierto Bol CIM 204 : Estabilidad de drogas oncológicas(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2013-03) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Bol CIM 205 : Azitromicina y riesgos cardíacos : valproato y embarazo(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2013-05) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Bol CIM 206 : Farmacovigilancia : anticonceptivos con drosperinona(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2013-07) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Bol CIM 207 : Eliminación de medicamentos oncológicos(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2013-09) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Bol CIM 208 : Bicalutamida(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2013-11) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Patient Safety: strategies for detection and prevention of medication errors in an Argentinian Hospital(Colegio de Farmacéuticos de la Provincia de Buenos Aires, 2014) Palchik, Valeria; Colautti, Marisel; Salamano, Mercedes; Bianchi, Mariela; Dolza, María Lucía; Traverso, María LuzÍtem Acceso Abierto Bol CIM 209 : Medicamentos vencidos y/o deteriorados : ¿cómo desecharlos?(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2014-01) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Bol CIM 210 : Lavado de manos con alcohol en gel(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2014-03) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Cold storage of liver microorgans in ViaSpan® and BG35 solutions. Study of ammonia metabolism during normothermic reoxygenation(Elsevier, 2014-03) Pizarro, María Dolores; Mediavilla, María Gabriela; Berardi, Florencia; Tiribelli, Claudio; Rodríguez, Joaquín Valentín; Mamprin, María E.Introduction. This work focuses on ammonia metabolism of Liver Microorgans (LMOs) after cold preservation in a normothermic reoxygenation system (NRS). We have previously reported the development of a novel preservation solution, Bes-Gluconate-PEG 35 kDa (BG35) that showed the same efficacy as ViaSpan® to protect LMOs against cold preservation injury. The objective of this work was to study mRNA levels and activities of two key Urea Cycle enzymes, Carbamyl Phosphate Synthetase I (CPSI) and Ornithine Transcarbamylase (OTC), after preservation of LMOs in BG35 and ViaSpan® and the ability of these tissue slices to detoxify an ammonia overload in a NRS model. Material and methods. After 48 h of cold storage (0°C in BG35 or ViaSpan®) LMOs were rewarmed in KHR containing an ammonium chloride overload (1 mM). We determined ammonium detoxification capacity (ADC), urea synthesis and enzyme activities and relative mRNA levels for CPSI and OTC. Results. At the end of reoxygenation LMOs cold preserved in BG35 have ADC and urea synthesis similar to controls. ViaSpan® group demonstrated a lower capacity to detoxify ammonia and to synthesize urea than fresh LMOs during the whole reoxygenation period which correlated with the lower mRNA levels and activities for CPSI and OTC observed for this group. Conclusion. We demonstrate that our preservation conditions (48 hours, BG35 solution, anoxia, 0ºC) did not affect ammonia metabolism of cold preserved LMOs maintaining the physiological and biochemical liver functions tested, which allows their future use as biological component of a BAL system.Ítem Acceso Abierto Bol CIM 211 : ¿Cómo administrar correctamente los comprimidos?(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2014-05) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Bol CIM 212 : Salud ósea y consumo de calcio(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2014-07) Centro de Información de Medicamentos - FCByF - UNRÍtem Acceso Abierto Bol CIM 214 : El riesgo del uso crónico de inhibidores de la bomba de protones(Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Información de Medicamentos, 2014-11) Centro de Información de Medicamentos - FCByF - UNR