(2017-06) Martí, María Belén; Lioi, Susana; Gerrard, Gabriela; Ceruti, María José; Diviani, Romina; Beloscar, Juan; D'Arrigo, Mabel; European Federation of Clinical Chemistry and Laboratory Medicine
Background: The pathogenesis of chronic chagasic cardiomyopathy (CCM) is controversial, there aren’t definitive proofs of which are the
necessary factors to reach the determinate stage. Each host genetic factors could actively participate in the evolution of
Chagas disease. Whereas the variability of phenotypic expression of the CCM could be because of genetic components of the
patient, we decided to do a descriptive study of genotype frequencies (GF) of SOD-Mn Ala-9-Val, the enzyme activities of
superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT), and as marker of inflammation factor tumor
necrosis (TNFalpha) in chagasic patients with cardiomyopathy (G1) and without cardiomyopathy (G2) compared with healthy
controls (CN).