Differential expression of DLG1 as a common trait in different human diseases: an encouraging issue in molecular pathology

Vista sencilla de ítem
dc.citation.titleBiological Chemistry
dc.citation.volume400
dc.creatorMarziali, Federico Emanuel
dc.creatorDizanzo, María Paula
dc.creatorCavatorta, Ana Laura
dc.creatorGardiol, Daniela
dc.date.accessioned2025-04-08T11:56:10Z
dc.date.available2025-04-08T11:56:10Z
dc.date.issued2019-04-02
dc.description.abstractHuman disc large (DLG1) is a scaffolding protein that through the interaction with diverse cell partners participates in the control of key cellular processes such as polarity, proliferation and migration. Experimental data have mainly identified DLG1 as a tumor suppressor. An outstanding point for DLG1 protein is that altered DLG1 expression and DLG1 gene mutations were observed in different pathologies, including cancer and neurological and immunological disorders. Evident changes in DLG1 abundance and/or cell localization were identified in a number of studies suggesting its participation in molecular mechanisms responsible for the development of such illnesses. In this review, we focus on some of the latest findings regarding DLG1 alterations in different diseases as well as its potential use as a biomarker for pathological progression. We further address the current knowledge on the molecular mechanisms regulating DLG1 expression and the posttranslational modifications that may affect DLG1 cell localization and functions. Despite the advances in this field, there are still open questions about the precise molecular link between alterations in DLG1 expression and the development of each specific pathology. The complete understanding of this concern will give us new scenarios for the design of promising diagnosis and therapeutic tools.
dc.description.filFil: Marziali, Federico Emanuel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET). Departamento de Microbiología; Argentina.
dc.description.filFil: Dizanzo, María Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET). Departamento de Microbiología; Argentina.
dc.description.filFil: Cavatorta, Ana Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET). Departamento de Microbiología; Argentina.
dc.description.filFil: Gardiol, Daniela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET). Departamento de Microbiología; Argentina.
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
dc.description.sponsorshipAgencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Agencia I+D+i)
dc.description.sponsorshipGobierno de la Provincia de Santa Fe
dc.description.sponsorshipInstituto Nacional del Cáncer (INC)
dc.description.sponsorshipFundación Bunge y Born
dc.description.versionpeerreviewed
dc.format.extent1-12
dc.identifier.citationMarziali, F. M., Dizanzo, M. P., Cavatorta, A. L. and Gardiol, D. (2019). Differential expression of DLG1 as a common trait in different human diseases: an encouraging issue in molecular pathology. Biological Chemistry, 400(6), 699-710. https://doi.org/10.1515/hsz-2018-0350
dc.identifier.e-issn1437-4315
dc.identifier.issn1431-6730
dc.identifier.urihttps://hdl.handle.net/2133/29225
dc.language.isoen
dc.publisherDe Gruyter
dc.relation.publisherversionhttps://doi.org/10.1515/hsz-2018-0350
dc.relation.publisherversionhttps://www.degruyterbrill.com/document/doi/10.1515/hsz-2018-0350/html
dc.rightsopenAccess
dc.rights.holderMarziali, Federico Emanuel
dc.rights.holderDizanzo, María Paula
dc.rights.holderCavatorta, Ana Laura
dc.rights.holderGardiol, Daniela
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.holderDe Gruyter
dc.rights.textAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCancer
dc.subjectDLG1
dc.subjectExpression
dc.subjectInflammation
dc.subjectNeurological disorders
dc.subjectRegulation
dc.titleDifferential expression of DLG1 as a common trait in different human diseases: an encouraging issue in molecular pathology
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

Archivos

Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
File - 10.1515_hsz-2018-0350.pdf
Tamaño:
367.43 KB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
Nombre:
license.txt
Tamaño:
3.87 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

(FBIOyF) Departamento de Ciencias Biológicas - Artículo de Revista
(FBIOyF) Departamento de Bioquímica Clínica - Artículos
(FBIOyF) Departamento de Química Biológica - Artículo de Revista