Advanced drug delivery systems for the management of local conditions

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dc.citation.titleTherapeutic Delivery
dc.contributor.orcidhttp://orcid.org/0000-0003-4808-2028
dc.contributor.orcidhttp://orcid.org/0000-0001-7493-3047
dc.contributor.orcidhttp://orcid.org/0000-0002-0766-4147
dc.contributor.orcidhttp://orcid.org/0000-0002-0414-8972
dc.creatorLopez Vidal, Lucía
dc.creatorJuskaite, Kornelija
dc.creatorRamöller, Inken K.
dc.creatorRealb, Daniel A.
dc.creatorMcKenna, Peter E.
dc.creatorPriotti, Josefina
dc.creatorDonnelly, Ryan F.
dc.creatorParedes, Alejandro J.
dc.date.accessioned2025-02-14T16:24:40Z
dc.date.available2025-02-14T16:24:40Z
dc.date.issued2024-12-29
dc.description.abstractLocalized disorders, even though originally confined to a specific body part, can progress into potentially life-threatening systemic disorders if treated inappropriately. Local treatment is often highly challenging due to poor penetration of therapeutic agents from their vehicles into the affected body site. Systemic treatment on the other hand often comes with unspecific side effects. The skin is the largest organ of the body, and conditions such as wounds and bacterial or fungal infections disrupt its natural barrier properties, important for the homeostasis of the human body. Advanced drug delivery systems for treating these conditions could greatly improve the treatment outcome and patient compliance. Other parts of the body that are of interest regarding localized treatment are, for example, the eyes along with mucosal tissues which are present in the vagina and lungs. Rather than focusing on specific diseases or parts of the body, this review provides an overview of the different drug delivery platforms that have been employed for enhanced local treatment. The following systems will be discussed: nanoparticle-based systems, such as nanocrystals, polymeric, lipidic, and inorganic nanoparticles, and nanogels; cyclodextrin inclusion complexes; and several devices like microarray patches, wound dressings, and films.
dc.description.filFil: Lopez Vidal, Lucía. Queen’s University Belfast. School of Pharmacy. Medical Biology Centre; United Kingdom.
dc.description.filFil: Juskaite, Kornelija. Queen’s University Belfast. School of Pharmacy. Medical Biology Centre; United Kingdom.
dc.description.filFil: Ramöller, Inken K. Queen’s University Belfast. School of Pharmacy. Medical Biology Centre; United Kingdom.
dc.description.filFil: Realb, Daniel A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA-CONICET); Argentina.
dc.description.filFil: Realb, Daniel A. Pill.AR Apotheke Revolution; Argentina.
dc.description.filFil: McKenna, Peter E. Queen’s University Belfast. School of Pharmacy. Medical Biology Centre; United Kingdom.
dc.description.filFil: Priotti, Josefina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Técnica Farmacéutica; Argentina.
dc.description.filFil: Donnelly, Ryan F. Queen’s University Belfast. School of Pharmacy. Medical Biology Centre; United Kingdom.
dc.description.filFil: Paredes, Alejandro J. Queen’s University Belfast. School of Pharmacy. Medical Biology Centre; United Kingdom.
dc.description.sponsorshiphttps://www.tandfonline.com/doi/epdf/10.1080/20415990.2024.2437978?needAccess=true
dc.description.sponsorshiphttps://doi.org/10.1080/20415990.2024.2437978
dc.description.versionpeerreviewed
dc.format.extent1-19
dc.identifier.issn2041-5990
dc.identifier.urihttps://hdl.handle.net/2133/28860
dc.language.isoen
dc.publisherTaylor and Francis
dc.relation.publisherversionhttps://doi.org/10.1080/20415990.2024.2437978
dc.relation.publisherversionhttps://www.tandfonline.com/doi/epdf/10.1080/20415990.2024.2437978?needAccess=true
dc.rightsopenAccess
dc.rights.holderLopez Vidal, Lucía
dc.rights.holderJuskaite, Kornelija
dc.rights.holderRamöller, Inken K.
dc.rights.holderRealb, Daniel A.
dc.rights.holderMcKenna, Peter E.
dc.rights.holderPriotti, Josefina
dc.rights.holderDonnelly, Ryan F.
dc.rights.holderParedes, Alejandro J.
dc.rights.holderUniversidad de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNanoparticles
dc.subjectNanocrystals
dc.subjectNanogels
dc.subjectCyclodextrins
dc.subjectMicroarray patches
dc.subjectMicroneedles
dc.subjectFilms
dc.subjectWound dressings
dc.titleAdvanced drug delivery systems for the management of local conditions
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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(FBIOyF) Departamento de Farmacia - Artículo de Revista