New alkaloids from a hawaiian fungal strain Aspergillus felis FM324

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dc.citation.titleFrontiers in Chemistryes
dc.citation.volume9
dc.creatorWang, Cong
dc.creatorSarotti, Ariel Marcelo
dc.creatorUz Zaman, Ahammad
dc.creatorWu, Xiaohua
dc.creatorCao, Shugeng
dc.date.accessioned2022-03-28T16:05:45Z
dc.date.available2022-03-28T16:05:45Z
dc.date.issued2021-08-09
dc.descriptionTwo new alkaloids tryptoquivaline Y (1) and pseurotin I (2), together with eight known compounds (3–10), were purified from a fungal strain Aspergillus felis FM324, which was isolated from a Hawaiian beach soil sample. The absolute configuration and physicochemical data of tryptoquivaline Z (3) were reported for the first time here in this paper. Compound 1 is an uncommon tryptoquivaline analog containing a 3-Oisobutanoyl group. The structures of the new compounds 1–2 and known compound 3 were elucidated through HRESIMS, NMR spectroscopy and ECD analysis. All the compounds were evaluated for their antiproliferative, antibacterial and NF-κB inhibitory activities. Compound 4 showed weak antibacterial activity against Staphylococcus aureus, methicillin resistant Staphylococcus aureus and Bacillus subtilis with the same MIC value of 59.2 µM. Compounds 3 and 2 inhibited NF-κB with IC50 values of 26.7 and 30.9 μM, respectively.es
dc.description.filFil: Wang, Cong. University of Hawaiʻi at Hilo. Daniel K. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Wang, Cong. Guangxi University for Nationalities. School of Chemistry and Chemical Engineering. Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products. Guangxi Key Laboratory of Chemistry and Engineering of Forest Products. State Ethnic Affairs Commission. Key Laboratory of Chemistry and Engineering of Forest Products; China.es
dc.description.filFil: Sarotti, Ariel Marcelo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentinaes
dc.description.filFil: Uz Zaman, Ahammad. University of Hawaiʻi at Hilo. Daniel K. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Wu, Xiaohua. University of Hawaiʻi at Hilo. Daniel K. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Cao, Shugeng. University of Hawaiʻi at Hilo. Daniel K. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.sponsorshipGuangxi for research bases and talents: AD20297036
dc.description.sponsorshipGuangxi Natural Science Foundation: 2019GXNSFBA185002
dc.description.sponsorshipUniversity of Hawaii Cancer Center (UHCC)
dc.description.sponsorshipDaniel K. Inouye College of Pharmacy (DKICP)
dc.description.sponsorshipHawaii IDeA Network for Biomedical Research Excellence III and IV (INBRE-III and INBRE-IV): 5P20GM103466
dc.formatapplication/pdf
dc.format.extent1-8es
dc.identifier.issn2296-2646es
dc.identifier.urihttp://hdl.handle.net/2133/23266
dc.language.isoenges
dc.publisherFrontiers Mediaes
dc.relation.publisherversionhttps://doi.org/10.3389/fchem.2021.724617
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fchem.2021.724617/full
dc.rightsopenAccesses
dc.rights.holderWang, Conges
dc.rights.holderSarotti, Ariel Marceloes
dc.rights.holderUz Zaman, Ahammades
dc.rights.holderWu, Xiaohuaes
dc.rights.holderCao, Shugenges
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAspergillus felises
dc.subjectTrichocomaceaees
dc.subjectAlkaloidses
dc.subjectAntiproliferativees
dc.subjectAntibacteriales
dc.subjectNF-κB inhibitory activitieses
dc.titleNew alkaloids from a hawaiian fungal strain Aspergillus felis FM324es
dc.typepublishedVersion
dc.typearticle
dc.typeartículo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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