New alkaloids from a hawaiian fungal strain Aspergillus felis FM324
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Frontiers Media
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Two new alkaloids tryptoquivaline Y (1) and pseurotin I (2), together with eight known
compounds (3–10), were purified from a fungal strain Aspergillus felis FM324, which was
isolated from a Hawaiian beach soil sample. The absolute configuration and
physicochemical data of tryptoquivaline Z (3) were reported for the first time here in
this paper. Compound 1 is an uncommon tryptoquivaline analog containing a 3-Oisobutanoyl group. The structures of the new compounds 1–2 and known compound
3 were elucidated through HRESIMS, NMR spectroscopy and ECD analysis. All the
compounds were evaluated for their antiproliferative, antibacterial and NF-κB inhibitory
activities. Compound 4 showed weak antibacterial activity against Staphylococcus
aureus, methicillin resistant Staphylococcus aureus and Bacillus subtilis with the same
MIC value of 59.2 µM. Compounds 3 and 2 inhibited NF-κB with IC50 values of 26.7 and
30.9 μM, respectively.
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