Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome

Vista sencilla de ítem
dc.citation.titleAnnals of Clinical Biochemistryes
dc.citation.volume54(5)es
dc.creatorPelusa, Héctor Fabián
dc.creatorPezzarini, Eleonora
dc.creatorBasiglio, Cecilia Lorena
dc.creatorMusuruana, Jorge
dc.creatorBearzotti, Mariela
dc.creatorSvetaz, María José
dc.creatorDaniele, Stella Maris
dc.creatorBottai, Hebe
dc.creatorArriaga, Sandra Mónica María
dc.date.accessioned2017-12-13T18:16:55Z
dc.date.available2017-12-13T18:16:55Z
dc.date.issued2016-11-02
dc.descriptionBackground: Antiphospholipid syndrome is an autoimmune disease characterized by thrombosis, fetal losses and thrombocytopenia associated to antiphospholipid antibodies. They are directed to phospholipids, such as cardiolipins (anticardiolipin) and lupus anticoagulant or to complexes formed by phospholipids and protein cofactors, such as b2 glycoprotein 1 (a-b2GP1) and annexin V (a-annexin V). These auto-antibodies may be considered as a family of antibodies involved in thrombotic events and antiphospholipid activity. On the other hand, some proangiogenic factors are involved in the normal development of placental vasculature, such as the vascular endothelial growth factor. Overexpression of vascular endothelial growth factor receptor in its soluble form (sVEGFR-1) has been associated to a higher antiangiogenic activity. Our aim was to analyse the association between anticardiolipin, lupus anticoagulant, a-b2GP1, a-annexin V and sVEGFR-1 with recurrent miscarriage before week 10 of gestation in females with antiphospholipid syndrome. Methods: We studied 24 females (primary or secondary antiphospholipid syndrome), who were divided into two groups: females with recurrent miscarriage before week 10 of gestation (M; n=12) and females with no history of fetal loss (NM; n=12). Anticardiolipin, a-b2GP1, a-annexin V and sVEGF-R1 concentrations were assessed by ELISA, while lupus anticoagulant was assessed by screening and confirmatory tests. Results: A significant association was observed between the number of positive biomarkers and the belonging group (P<0.05). Besides, a positive result for lupus anticoagulant and a-b2GP1 was found to be significantly associated to the M group (P<0.05). Conclusions: Lupus anticoagulant and a-b2GP1 may be implicated in pregnancies complicated by recurrent miscarriage in females with antiphospholipid syndrome.es
dc.description.filFil: Pelusa, Héctor Fabián. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área de Bioquímica Clínica; Argentinaes
dc.description.filFil: Pezzarini, Eleonora. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área de Bioquímica Clínica; Argentinaes
dc.description.filFil: Basiglio, Cecilia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área de Bioquímica Clínica; Argentinaes
dc.description.filFil: Basiglio, Cecilia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE‑CONICET); Argentinaes
dc.description.filFil: Musuruana, Jorge. Provincia de Santa Fe. Hospital J. B. Iturraspe. Servicio de Reumatología y Enfermedades Autoinmunes Sistémicas; Argentinaes
dc.description.filFil: Bearzotti, Mariela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento Bioquímica Clínica; Argentinaes
dc.description.filFil: Svetaz, María José. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento Bioquímica Clínica; Argentinaes
dc.description.filFil: Daniele, Stella Maris. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área de Bioquímica Clínica; Argentinaes
dc.description.filFil: Bottai, Hebe. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Estadística y Procesamiento de Datos; Argentinaes
dc.description.filFil: Arriaga, Sandra Mónica María. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área de Bioquímica Clínica; Argentinaes
dc.description.sponsorshipUniversidad Nacional de Rosarioes
dc.formatapplication/pdf
dc.format.extent577-583es
dc.identifier.issn1758-1001es
dc.identifier.urihttp://hdl.handle.net/2133/10231
dc.language.isoenges
dc.publisherSAGEes
dc.relation.publisherversionhttp://journals.sagepub.com/doi/abs/10.1177/0004563216672248?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&es
dc.relation.publisherversionhttps://doi.org/10.1177/0004563216672248es
dc.rightsopenAccesses
dc.rights.holderSAGEes
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticases
dc.rights.holderPelusa, Héctor Fabiánes
dc.rights.holderPezzarini, Eleonoraes
dc.rights.holderBasiglio, Cecilia Lorenaes
dc.rights.holderMusuruana, Jorgees
dc.rights.holderBearzotti, Marielaes
dc.rights.holderSvetaz, María Josées
dc.rights.holderDaniele, Stella Marises
dc.rights.holderBottai, Hebees
dc.rights.holderArriaga, Sandra Mónica Maríaes
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ar/*
dc.subjectPregnancyes
dc.subjectImmunoassayes
dc.subjectCoagulation Testinges
dc.titleAntiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndromees
dc.typearticle
dc.typeartículo
dc.typeacceptedVersion
dc.type.collectionarticulo
dc.type.versionacceptedVersiones

Archivos

Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Main text Pelusa et al revised version - copia.pdf
Tamaño:
326.37 KB
Formato:
Adobe Portable Document Format
Descripción:
Versión Revisada
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
Nombre:
license.txt
Tamaño:
3.59 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

(FBIOyF) Departamento de Bioquímica Clínica - Artículos
CIUNR - Ciencias Naturales - Artículos de Revista