Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field

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dc.citation.titleCancer Investigationes
dc.citation.volume32es
dc.creatorRico, María José
dc.creatorPerroud, Herman A
dc.creatorMainetti, Leandro Ernesto
dc.creatorRozados, Viviana R.
dc.creatorScharovsky, O. Graciela
dc.date.accessioned2018-04-19T17:01:01Z
dc.date.available2018-04-19T17:01:01Z
dc.date.issued2014-02-05
dc.descriptionMetronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis growth, survival, and toxicity. Metronomic chemotherapy with Cyclophosphamide + Celecoxib (Cy + Cel) showed higher antimetastatic power than Cyclophosphamide + Doxorubicin (Cy + Dox), while being similar in other aspects. That difference, plus the advantage that represents its oral administration, suggests that the Cy + Cel combination is more suitable than Cy + Dox for metronomic chemotherapy of mammary tumors and could be proposed to the translation to the clinic.es
dc.description.filFil: Rico, María José. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Perroud, Herman A. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Mainetti, Leandro Ernesto. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Argentinaes
dc.description.filFil: Rozados, Viviana R. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Scharovsky, Graciela Olga. Universidad Nacional de Rosario. Consejo de Investigaciones UNR, Facultad de Ciencias Médicas; Argentinaes
dc.description.sponsorshipUniversidad Nacional de Rosarioes
dc.formatapplication/pdf
dc.format.extent92-98es
dc.identifier.issn0735-7907es
dc.identifier.urihttp://hdl.handle.net/2133/11113
dc.language.isoenges
dc.publisherTaylor & Francises
dc.relation.publisherversionhttps://doi.org/10.3109/07357907.2013.877480es
dc.rightsopenAccesses
dc.rights.holderAutoreses
dc.rights.holderTaylor & Francises
dc.subjectMetronomic chemotherapyes
dc.subjectCombined treatmentes
dc.subjectCyclophosphamidees
dc.subjectDoxorubicines
dc.subjectCelecoxibes
dc.subject Mammary adenocarcinomases
dc.titleComparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Fieldes
dc.typearticle
dc.typeartículo
dc.typeacceptedVersion
dc.type.collectionarticulo
dc.type.versionacceptedVersiones

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CIUNR - Ciencias Naturales - Artículos de Revista
FCM - SCTeI - Artículo de Revista de Investigación