Regulatory T cells but not NKT I cells are modulated by a single low-dose cyclophosphamide in a B cell lymphoma tumor-model

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dc.contributor.authorRico, María José
dc.contributor.authorRozados, Viviana R.
dc.contributor.authorMainetti, Leandro Ernesto
dc.contributor.authorZacarías Fluck, Mariano
dc.contributor.authorMatar, Pablo
dc.contributor.authorScharovsky, O. Graciela
dc.date.accessioned2012-08-24T14:59:09Z
dc.date.available2012-08-24T14:59:09Z
dc.date.issued2012-03
dc.description.abstractAim: Experimental and clinical studies showed that the administration of cyclophosphamide (Cy) in low doses leads to an enhancement of the antitumor immune response. Our objective was to study the modulation, if any, by low dose Cy, of T regulatory (Treg) and natural killer T (NKT) I cells, two cell populations of the innate immune response with opposing effects on the tumors, in a rat B cell lymphoma model. Methods: Inbred e rats were challenged s.c. with L-TACB lymphoma and on day 14 animals were distributed in two groups. Treated: injected i.p. with cyclophosphamide (10mg/kg of body weight) and Control: injected i.p. with saline. Blood samples were taken from days 0 to 21 and the percentage of T regulatory and natural killer T I cells were determined by flow cytometry. Results: We found that the increase of natural and inducible T regulatory cells of peripheral blood achieved during tumor growth was significantly downregulated by cyclophosphamide. On the contrary, natural killer T I cells were not modulated by the treatment. Conclusion: The antimetastatic effect of a single low dose of Cy would be due, at least in part, to downregulation of natural and inducible T regulatory cells.es
dc.description.peerreviewedPeer reviewedes
dc.description.sponsorshipCibic S.A. This work was supported by a grant from Universidad Nacional de Rosario to O.G. Scharovsky.es
dc.formatapplication/pdf
dc.identifier.issn1812-9269
dc.identifier.urihttp://hdl.handle.net/2133/2006
dc.language.isoenes
dc.publisherMORION LLCes
dc.rightsopenAccess
dc.rights.text© Experimental Oncology, 2012es
dc.subjectT regulatory cellses
dc.subjectNKT I cellses
dc.subjectcyclophosphamidees
dc.subjectlymphomaes
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents, Alkylating/administration & dosage
dc.subject.meshCyclophosphamide/administration & dosage
dc.subject.meshDisease Models, Animal
dc.subject.meshFemale
dc.subject.meshLymphoma, B-Cell/drug therapy
dc.subject.meshLymphoma, B-Cell/immunology
dc.subject.meshNatural Killer T-Cells/immunology
dc.subject.meshRats
dc.subject.meshT-Lymphocytes, Regulatory/drug effects
dc.subject.meshT-Lymphocytes, Regulatory/immunology
dc.titleRegulatory T cells but not NKT I cells are modulated by a single low-dose cyclophosphamide in a B cell lymphoma tumor-modeles
dc.typearticle
dc.typeartículo
dc.typepublishedVersion

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FCM - Instituto de Genética Experimental - Artículos
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