Achievements and challenges in the use of metronomics for the treatment of breast cancer

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dc.citation.titleBiochemical Pharmacologyes
dc.creatorScharovsky, O. Graciela
dc.creatorRico, María José
dc.creatorMainetti, Leandro Ernesto
dc.creatorPerroud, Herman A
dc.creatorRozados, Viviana R.
dc.date.accessioned2020-11-27T15:51:57Z
dc.date.available2020-11-27T15:51:57Z
dc.date.issued2020-03
dc.descriptionTwo interesting therapeutic proposals for cancer treatment emerged at the beginning of the 21st century. The first one was metronomic chemotherapy, which refers to the chronic administration of chemotherapeutic agents, in low doses, without extended drug-free periods. Then, the idea of drug repositioning in oncology, the use of well-known drugs that were created for other uses to be utilized in oncology, gained strength. Shortly after, the two strategies were merged in one, named metronomics. Both approaches share several features which make metronomics an appealing choice for cancer treatment: use of known and approved drugs, thus diminishing the time necessary to enter to the clinic, therapeutic effect, low toxicity, oral administration, better life quality, low costs because of the use of, generally, out of patent drugs, possibility of use, even in countries with very low economic resources. Many chemotherapy and repurposed drugs were tested with metronomics approaches for the treatment of mammary cancer, the most common malignancy in women worldwide, leading to high rates of mortality. The wide range of therapeutic models studied, paralleled the wide range of responses obtained, like tumor growth and metastasis inhibition, overall survival increase, lack of toxicity, better life quality, among others. The accomplishments reached, and the challenges faced by researchers, are discussed.es
dc.description.filFil: Scharovsky, O. Graciela. Universidad Nacional de Rosario. Consejo de Investigaciones UNR, Facultad de Ciencias Médicas; Argentinaes
dc.description.filFil: Rico, María José. Institute of Experimental Genetics.School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Mainetti, Leandro Ernesto. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentinaes
dc.description.filFil: Perroud, Herman A. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentinaes
dc.description.filFil: Rozados, Viviana R. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentinaes
dc.formatapplication/pdf
dc.format.extent1-11es
dc.identifier.issn1873-2968es
dc.identifier.urihttp://hdl.handle.net/2133/19359
dc.language.isospaes
dc.publisherElsevieres
dc.relation.publisherversionhttps://doi.org/10.1016/j.bcp.2020.113909es
dc.rightsopenAccesses
dc.rights.holderElsevieres
dc.subjectMetronomic chemotherapyes
dc.subjectDrug repositioninges
dc.subjectBreast canceres
dc.subjectTriple negativees
dc.subjectPreclinical-clinicales
dc.titleAchievements and challenges in the use of metronomics for the treatment of breast canceres
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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CIUNR - Ciencias Naturales - Artículos de Revista
FCM - Instituto de Genética Experimental - Artículos