Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas

dc.citation.titleAnnals of Oncologyes
dc.citation.volume24es
dc.creatorMainetti, Leandro Ernesto
dc.creatorRico, María José
dc.creatorFernández Zenobi, María Virginia
dc.creatorPerroud, Herman A.
dc.creatorRoggero, Eduardo
dc.creatorRozados, Viviana R.
dc.creatorScharovsky, O. Graciela
dc.date.accessioned2018-04-13T12:58:34Z
dc.date.available2018-04-13T12:58:34Z
dc.date.issued2013-09-01
dc.descriptionMetronomic chemotherapy (MCT) involves the chronic administration of doses of chemotherapy drugs that are below the maximum tolerated dose (MTD), at frequent and regular intervals, without extended rest periods [1]. It aims to achieve a balance between efficacy in tumor killing and lack of toxicity. The inhibition of angiogenesis would explain its therapeutic effect [2, 3]. We have demonstrated the antitumor efficacy of MCT with cyclophosphamide (Cy) as a single drug [4] and in combination with celecoxib on mice mammary adenocarcinomas (MA) [5]. Considering the high incidence of mammary tumors in humans, in this study, we analyze the therapeutic efficacy, toxicity and mechanism/s of action of MCT combining Cy and doxorubicin (Dox), in mouse MA tumor-models.es
dc.description.filFil: Mainetti, Leandro Ernesto. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Argentinaes
dc.description.filFil: Mainetti, Leandro Ernesto. Departments of Urology and Pathology. Wayne State University School of Medicine; Detroit; MI; USAes
dc.description.filFil: Rico, María José. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Fernández Zenobi, María Virginia. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Perroud, Herman A. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Roggero, Eduardo. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Rozados, Viviana R. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Scharovsky, Graciela Olga. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.sponsorshipUniversidad Nacional de Rosarioes
dc.formatapplication/pdf
dc.format.extent2310–2316es
dc.identifier.issn1479-6694es
dc.identifier.urihttp://hdl.handle.net/2133/11094
dc.language.isoenges
dc.publisherOxford University Presses
dc.relation.publisherversionhttps://doi.org/10.1093/annonc/mdt164es
dc.rightsopenAccesses
dc.rights.holder© Oxford University Press. Autoreses
dc.subjectAngiogenesises
dc.subjectCyclophosphamidees
dc.subjectdoxorubicines
dc.subjecttoxicityes
dc.titleTherapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomases
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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