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Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas

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dc.citation.titleAnnals of Oncologyes
dc.citation.volume24es
dc.creatorMainetti, Leandro Ernesto
dc.creatorRico, María José
dc.creatorFernández Zenobi, María Virginia
dc.creatorPerroud, Herman A.
dc.creatorRoggero, Eduardo
dc.creatorRozados, Viviana R.
dc.creatorScharovsky, O. Graciela
dc.date.accessioned2018-04-13T12:58:34Z
dc.date.available2018-04-13T12:58:34Z
dc.date.issued2013-09-01
dc.descriptionMetronomic chemotherapy (MCT) involves the chronic administration of doses of chemotherapy drugs that are below the maximum tolerated dose (MTD), at frequent and regular intervals, without extended rest periods [1]. It aims to achieve a balance between efficacy in tumor killing and lack of toxicity. The inhibition of angiogenesis would explain its therapeutic effect [2, 3]. We have demonstrated the antitumor efficacy of MCT with cyclophosphamide (Cy) as a single drug [4] and in combination with celecoxib on mice mammary adenocarcinomas (MA) [5]. Considering the high incidence of mammary tumors in humans, in this study, we analyze the therapeutic efficacy, toxicity and mechanism/s of action of MCT combining Cy and doxorubicin (Dox), in mouse MA tumor-models.es
dc.description.filFil: Mainetti, Leandro Ernesto. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Argentinaes
dc.description.filFil: Mainetti, Leandro Ernesto. Departments of Urology and Pathology. Wayne State University School of Medicine; Detroit; MI; USAes
dc.description.filFil: Rico, María José. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Fernández Zenobi, María Virginia. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Perroud, Herman A. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Roggero, Eduardo. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Rozados, Viviana R. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.filFil: Scharovsky, Graciela Olga. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentinaes
dc.description.sponsorshipUniversidad Nacional de Rosarioes
dc.formatapplication/pdf
dc.format.extent2310–2316es
dc.identifier.issn1479-6694es
dc.identifier.urihttp://hdl.handle.net/2133/11094
dc.language.isoenges
dc.publisherOxford University Presses
dc.relation.publisherversionhttps://doi.org/10.1093/annonc/mdt164es
dc.rightsopenAccesses
dc.rights.holder© Oxford University Press. Autoreses
dc.subjectAngiogenesises
dc.subjectCyclophosphamidees
dc.subjectdoxorubicines
dc.subjecttoxicityes
dc.titleTherapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomases
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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CIUNR - Ciencias Naturales - Artículos de Revista
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