Aquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trends

dc.citation.titleOxidative Medicine and Cellular Longevityes
dc.citation.volume2018es
dc.creatorTamma, Grazia
dc.creatorValenti, Giovanna
dc.creatorGrossini, Elena
dc.creatorDonnini, Sandra
dc.creatorMarino, Angela
dc.creatorMarinelli, Raúl A.
dc.creatorCalamita, Giuseppe
dc.date.accessioned2021-03-01T21:43:03Z
dc.date.available2021-03-01T21:43:03Z
dc.date.issued2018-03-27
dc.descriptionReactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.es
dc.description.filFil: Tamma, Grazia. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharmaceutics; Italy.es
dc.description.filFil: Valenti, Giovanna. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharmaceutics; Italy.es
dc.description.filFil: Elena, Grossini. University of Eastern Piedmont. Department of Translational Medicine; Italy.es
dc.description.filFil: Donnini, Sandra. University of Siena. Department of Life Sciences; Italy.es
dc.description.filFil: Marino, Angela. University of Messina. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences; Italy.es
dc.description.filFil: Marinelli, Raúl A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE -CONICET); Argentina.es
dc.description.filFil: Calamita, Giuseppe. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharmaceutics; Italy.es
dc.description.sponsorshipFondazione Cariplo and Daniel & Nina Carasso Foundation: project LeGeReTe #1507-200 AF, #FC 2015-2440es
dc.description.sponsorship“Thought for Food” Initiative of Agropolis Foundation through the “Investissements d’avenir” programme: ANR-10-LABX-0001-01es
dc.formatapplication/pdf
dc.format.extent1-14es
dc.identifier.issn1942-0994es
dc.identifier.urihttp://hdl.handle.net/2133/19959
dc.language.isoenges
dc.publisherHindawies
dc.relation.publisherversionhttps://doi.org/10.1155/2018/1501847es
dc.relation.publisherversionhttps://www.hindawi.com/journals/omcl/2018/1501847/es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderTamma, Graziaes
dc.rights.holderValenti, Giovannaes
dc.rights.holderElena, Grossinies
dc.rights.holderDonnini, Sandraes
dc.rights.holderMarino, Angelaes
dc.rights.holderMarinelli, Raúl A.es
dc.rights.holderCalamita, Giuseppees
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAquaporin Membrane Channelses
dc.subjectOxidative Stresses
dc.subjectSignalinges
dc.subjectAginges
dc.titleAquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trendses
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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