Aquaporin membrane channels in oxidative stress, cell signaling, and aging: recent advances and research trends
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Hindawi
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Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological
and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling
pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover,
increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty,
hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing
novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review
focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane
transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and
pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action
on AQPs are also reviewed.
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