Preliminary study of alterations in human red blood cells by irradiation with high energy photons

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dc.citation.titleAnais Encontro Anual da Biofísica 2019es
dc.citation.volume2 (1)es
dc.contributor.organizerSociedade Brasileira de Biofísicaes
dc.contributor.otherD'Arrigo, Mabel. Colaboración en preparación de muestras biológicas
dc.contributor.otherCastellani, Daniel. Colaboración en la fabricación del dispositivo adaptador de muestra.
dc.creatorRiquelme, Bibiana Doris
dc.creatorEstrada, Ezequiel
dc.creatorCastellini, Horacio V.
dc.creatorAcosta, Andrea
dc.creatorChinelatto, Alejandro
dc.creatorTack, Ivan
dc.creatorBorraz, Javier
dc.creatorDi Tullio, Liliana
dc.creatorGalassi, Mariel Elisa
dc.date.accessioned2019-11-22T22:41:01Z
dc.date.available2019-11-22T22:41:01Z
dc.date.issued2019
dc.description.abstractIntroduction: Transfusion-associated graft-versus-host disease can be prevented by treating cellular blood products with gamma irradiation. A wide range of gamma irradiation dose levels are used in routine practice, but gamma irradiation dose of 25 Gy may be required to completely inactivate T cells in Red Blood Cells (RBC) units (Pelszynski, M. et al., 1994). This process decreases the survival of the RBC transfused, so it is crucial to understand the alterations caused by gamma irradiation to the erythrocyte membrane. In previous works, the biochemical and hematological effects of gamma irradiation at different storage periods were studied. It was observed that irradiation of the erythrocytes increases red cells hemolysis and leakage of intracellular potassium (Adams, F. et al., 2015; Yousuf, R. et al., 2018). The mechanisms through which irradiation causes the loss of RBC viability could be related to the primary effects of radiation. Gamma and X-ray Ionizing radiation cause indirect damage through the reactive oxygen species generated by water radiolysis (Anand, A.J. et al., 1997). The reduced deformability of RBC after irradiation could be related to the interaction of the oxygen-derived radicals with the membranes, affecting their mechanical properties and leading to deformability impairment (Kim, Y.-K. et al., 2008). In a recent work (AlZahrani K. et al., 2017), nanoestructural changes in the RBC membrane at different doses of gamma irradiation were observed using atomic force microscopy. The images shown that the roughness of the cell membrane increased dramatically with increasing doses, affecting their biophysical properties. However, more research is needed to understand the effects of gamma irradiation on the mechanical and adhesion properties of RBC. For this reason, in the present work we set out to measure the mechanical and aggregation parameters of human red blood cells exposed to gamma photons in different doses in order to determine the possible alterations due to radiation.es
dc.description.filFil: Riquelme, Bibiana Doris. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Física Rosario (IFIR-CONICET); Argentina.es
dc.description.filFil: Estrada, Ezequiel. Universidad Nacional de Rosario. Facultad de Ciencias Exactas, Ingeniería y Agrimensura; Argentina.es
dc.description.filFil: Castellini, Horacio V. Universidad Nacional de Rosario. Facultad de Ciencias Exactas, Ingeniería y Agrimensura; Argentina.es
dc.description.filFil: Acosta, Andrea. Centro Regional de Hemoterapia de Santa Fe; Argentina.es
dc.description.filFil: Chinelatto, Alejandro. Centro Regional de Hemoterapia de Santa Fe; Argentina.es
dc.description.filFil: Tack, Ivan, Ivan. Centro Regional de Hemoterapia de Santa Fe; Argentina.es
dc.description.filFil: Borraz, Javier. Centro Regional de Hemoterapia de Santa Fe; Argentina.es
dc.description.filFil: Di Tullio, Liliana. Centro Regional de Hemoterapia de Santa Fe; Argentina.es
dc.description.filFil: Galassi, Mariel Elisa. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Física Rosario (IFIR-CONICET); Argentina.es
dc.description.filFil: Galassi, Mariel Elisa. Universidad Nacional de Rosario. Facultad de Ciencias Exactas, Ingeniería y Agrimensura; Argentina.es
dc.formatapplication/pdf
dc.format.extent107-108es
dc.identifier.issn2526-6071es
dc.identifier.urihttp://hdl.handle.net/2133/17140
dc.language.isoenges
dc.publisherBlucheres
dc.relation.publisherversionhttps://www.proceedings.blucher.com.br/article-details/preliminary-study-of-alterations-in-human-red-blood-cells-by-irradiation-with-high-energy-photons-30605es
dc.relation.publisherversionhttp://dx.doi.org/10.5151/biofisica2019-30es
dc.rightsopenAccesses
dc.rights.holderRiquelme, Bibiana Dorises
dc.rights.holderEstrada, Ezequieles
dc.rights.holderCastellini, Horacio V.es
dc.rights.holderAcosta, Andreaes
dc.rights.holderChinelatto, Alejandroes
dc.rights.holderTack, Ivanes
dc.rights.holderBorraz, Javieres
dc.rights.holderDi Tullio, Lilianaes
dc.rights.holderGalassi, Mariel Elisaes
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticases
dc.rights.holderBlucheres
dc.rights.textAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es*
dc.subjectRed Blood Cellses
dc.subjectErythrocyteses
dc.subjectHigh Energy Photonses
dc.subjectRadiation Effectses
dc.titlePreliminary study of alterations in human red blood cells by irradiation with high energy photonses
dc.typeconferenceObject
dc.typedocumento de conferencia
dc.typepublishedVersion
dc.type.collectioncomunicaciones
dc.type.versionpublishedVersiones

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(FBIOyF) Departamento de Química Física - Comunicaciones
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