A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062

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dc.citation.titleMoleculeses
dc.citation.volume22(7)es
dc.creatorLi, Chun-shun
dc.creatorSarotti, Ariel Marcelo
dc.creatorYang, Baojun
dc.creatorTurkson, James
dc.creatorCao, Shugeng
dc.date.accessioned2020-12-22T14:51:11Z
dc.date.available2020-12-22T14:51:11Z
dc.date.issued2017-07-12
dc.descriptionA new N-methoxypyridone analog (1), together with four known compounds, was isolated from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. The structure of the new compound was elucidated as 11S-hydroxy-1-methoxyfusaricide (1) by extensive spectroscopic analysis and comparison with the literature. The absolute configuration of 1 was determined by comparison with the experimental and calculated ECD spectra. The absolute configuration of compound 3 was investigated and renamed as (+)-epipyridone by comparison of the optical rotation and CD spectrum with those of 1. The other known compounds were identified as epicoccarine B (2), D8646-2-6 (4), and iso-D8646-2-6 (5). Compounds 4 and 5 showed modest inhibitory activity towards pathogenic fungi. Epicoccarine B (2) inhibited A2780 and TK-10 with an IC50 value of 22 ĀµM.es
dc.descriptionPara citar este articulo: Li, C.; Sarotti, A.M.; Yang, B.; Turkson, J.; Cao, S. A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. Molecules 2017, 22, 1166.
dc.description.filFil: Li, Chun-shun. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Li, Chun-shun. University of Hawaii Cancer Center. Cancer Biology Program; United States.es
dc.description.filFil: Sarotti, Ariel Marcelo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquƭmicas y FarmacƩuticas. Instituto de Quƭmica Rosario (IQUIR -CONICET); Argentina.es
dc.description.filFil: Yang, Baojun. University of Hawaii Cancer Center. Cancer Biology Program; United States.es
dc.description.filFil: Turkson, James. University of Hawaii Cancer Center. Cancer Biology Program; United States.es
dc.description.filFil: Cao, Shugeng. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Cao, Shugeng. University of Hawaii Cancer Center. Cancer Biology Program; United States.es
dc.description.sponsorshipUniversity of Hawaii Cancer Centeres
dc.description.sponsorshipUniversity of Hawaii at Hiloes
dc.description.sponsorshipVictoria S. and Bradley L. Geist Foundation: 15ADVC-74420 and 17CON-86295es
dc.description.sponsorshipNational Institutes of Health (NIH)/National Cancer Institute (NCI): Grant CA128865es
dc.formatapplication/pdf
dc.format.extent1-8es
dc.identifier.issn1420-3049es
dc.identifier.urihttp://hdl.handle.net/2133/19532
dc.language.isoenges
dc.publisherMDPIes
dc.relation.publisherversionhttps://doi.org/10.3390/molecules22071166es
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/22/7/1166es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderLi, Chunshunes
dc.rights.holderSarotti, Ariel Marceloes
dc.rights.holderYang, Baojunes
dc.rights.holderTurkson, Jameses
dc.rights.holderCao, Shugenges
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectEndophytic Fungies
dc.subjectCoculture Techniqueses
dc.subjectPyridoneses
dc.subjectTetramic Acides
dc.subjectHawaiies
dc.titleA new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062es
dc.typearticle
dc.typeartĆ­culo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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