A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062
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A new N-methoxypyridone analog (1), together with four known compounds, was isolated
from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum
FT1062. The structure of the new compound was elucidated as 11S-hydroxy-1-methoxyfusaricide (1)
by extensive spectroscopic analysis and comparison with the literature. The absolute configuration of
1 was determined by comparison with the experimental and calculated ECD spectra. The absolute
configuration of compound 3 was investigated and renamed as (+)-epipyridone by comparison of
the optical rotation and CD spectrum with those of 1. The other known compounds were identified
as epicoccarine B (2), D8646-2-6 (4), and iso-D8646-2-6 (5). Compounds 4 and 5 showed modest
inhibitory activity towards pathogenic fungi. Epicoccarine B (2) inhibited A2780 and TK-10 with
an IC50 value of 22 µM.
Para citar este articulo: Li, C.; Sarotti, A.M.; Yang, B.; Turkson, J.; Cao, S. A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. Molecules 2017, 22, 1166.
Para citar este articulo: Li, C.; Sarotti, A.M.; Yang, B.; Turkson, J.; Cao, S. A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. Molecules 2017, 22, 1166.
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