Stone fruit as biofactories of phytochemicals with potential roles in human nutrition and health

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dc.citation.titleFrontiers in Plant Science
dc.citation.volume1-21
dc.creatorLara, María Valeria
dc.creatorBonghi, Claudio
dc.creatorFamiani, Franco
dc.creatorVizzotto, Giannina
dc.creatorWalker, Robert P.
dc.creatorDrincovich, María Fabiana
dc.date.accessioned2024-04-11T17:47:18Z
dc.date.available2024-04-11T17:47:18Z
dc.date.issued2020-09-02
dc.description.abstractComprehensive knowledge of the critical properties of the active pharmaceutical ingredients is a requirement within the modern concept of quality. Praziquantel hemihydrate (HH) and monohydrate (MH) are new solid forms of this antihelmintic agent, which have better solubility properties than the commercial anhydrous solid form (polymorph A). The thermal stability of the hydrates was evaluated, aiming to understand any possible transformation (amorphization, change to a less soluble form). Therefore, HH and MH were prepared along with the related anhydrous solid forms A and B, and characterized employing solid-state nuclear magnetic resonance, powder X-ray diffraction, mid and near infrared spectroscopy, thermal methods and the intrinsic dissolution rate. The transformations of HH and MH under thermal stress conditions were monitored through a variable temperature infrared spectroscopy approach, assisted by multivariate curve resolution with alternating least squares (MCR-ALS), finding that HH undergoes a two-step transformation (HH→B→A) to form A, whereas MH dehydrates directly into form A. This was further confirmed by conventional calorimetric methods (differential scanning calorimetry and thermogravimetry) and powder X-ray diffractometry. The impact of changes in the stressed solid forms and their dissolution rates was also assessed. Significant differences in dissolution performance were found regarding the solid forms produced as a consequence of thermally-induced dehydration.
dc.description.filFil: Lara, María Valeria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Fotosintéticos y Bioquímicos; Argentina.
dc.description.filFil: Bonghi, Claudio. University of Padova Agripolis. Department of Agronomy, Food, Natural Resources, Animals and Environment; Italy.
dc.description.filFil: Famiani, Franco. Università degli Studi di Perugia. Dipartimento di Scienze Agrarie, Alimentari e Ambientali; Italy.
dc.description.filFil: Vizzotto, Giannina. University of Udine. Department of Agricultural, Food, Environmental, and Animal Sciences; Italy.
dc.description.filFil: Walker, Robert P. Università degli Studi di Perugia. Dipartimento di Scienze Agrarie, Alimentari e Ambientali; Italy.
dc.description.filFil: Drincovich, María Fabiana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Fotosintéticos y Bioquímicos; Argentina.
dc.identifier.issn1664-462X
dc.identifier.urihttps://hdl.handle.net/2133/26869
dc.language.isoen
dc.publisherFrontiers Media
dc.rightsopenAccess
dc.rights.holderLara, María Valeria
dc.rights.holderBonghi, Claudio
dc.rights.holderFamiani, Franco
dc.rights.holderVizzotto, Giannina
dc.rights.holderWalker, Robert P.
dc.rights.holderDrincovich, María Fabiana
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectChlorogenic acid
dc.subjectFlavonoids
dc.subjectAnthocyanins
dc.subjectCarotenoids
dc.subjectPostharvest
dc.subjectVolatiles
dc.subjectHealth promoting
dc.subjectCyanogenic compounds
dc.titleStone fruit as biofactories of phytochemicals with potential roles in human nutrition and health
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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