Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals

dc.citation.titleOpen Biology
dc.citation.volume6(7)
dc.creatorNajle, Sebastián R.
dc.creatorMolina, María Celeste
dc.creatorRuiz-Trillo, Iñaki
dc.creatorUttaro, Antonio Domingo
dc.date.accessioned2021-03-15T22:23:42Z
dc.date.available2021-03-15T22:23:42Z
dc.date.issued2016-07-01
dc.descriptionSterols are essential for several physiological processes in most eukaryotes. Sterols regulate membrane homeostasis and participate in different signalling pathways not only as precursors of steroid hormones and vitamins, but also through its role in the formation of lipid rafts. Two major types of sterols, cholesterol and ergosterol, have been described so far in the opisthokonts, the clade that comprise animals, fungi and their unicellular relatives. Choles terol predominates in derived bilaterians, whereas ergosterol is what generally defines fungi. We here characterize, by a combination of bioinformatic and bio chemical analyses, the sterol metabolism in the filasterean Capsaspora owczarzaki, a close unicellular relative of animals that is becoming a model organism. We found that C. owczarzaki sterol metabolism combines enzymatic activities that are usually considered either characteristic of fungi or exclusive to metazoans. Moreover, we observe a differential transcriptional regulation of this metabolism across its life cycle. Thus, C. owczarzaki alternates between synthesizing 7-dehydrocholesterol de novo, which happens at the cystic stage, and the partial conversion—via a novel pathway—of incorporated cholesterol into ergosterol, the characteristic fungal sterol, in the filopodial and aggregative stages.es
dc.description.filFil: Najle, Sebastián R. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.
dc.description.filFil: Najle, Sebastián R. Consejo Superior de Investigaciones Científicas (CSIC) - Universitat Pompeu Fabra. Institut de Biologia Evolutiva (IBE); España.
dc.description.filFil: Molina, María Celeste. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.
dc.description.filFil: Ruiz-Trillo, Iñaki. Consejo Superior de Investigaciones Científicas (CSIC) - Universitat Pompeu Fabra. Institut de Biologia Evolutiva (IBE); España.
dc.description.filFil: Ruiz-Trillo, Iñaki. Universitat de Barcelona. Departament de Genética; España.
dc.description.filFil: Ruiz-Trillo, Iñaki. Institució Catalana de Recerca i Estudis Avançats (ICREA); España.
dc.description.filFil: Uttaro, Antonio Domingo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT 2012-1301 y PICT 2014-1311es
dc.description.sponsorshipEuropean Research Council Consolidator Grant: ERC-2012-Co -616960es
dc.description.sponsorshipMinisterio de Economía Industria y Competitividad (MINECO): grant BFU2014-57779-Pes
dc.description.sponsorshipFondo Europeo de Desarrollo Regional (FEDER)es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)es
dc.description.sponsorshipSecretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya: Project 2014 SGR 619es
dc.formatapplication/pdf
dc.format.extent1-14
dc.identifier.issn2046-2441
dc.identifier.urihttp://hdl.handle.net/2133/20171
dc.language.isoenges
dc.publisherThe Royal Societyes
dc.relation.publisherversionhttps://doi.org/10.1098/rsob.160029es
dc.relation.publisherversionhttps://royalsocietypublishing.org/doi/10.1098/rsob.160029es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderNajle, Sebastián R.es
dc.rights.holderMolina, María Celestees
dc.rights.holderRuiz-Trillo, Iñakies
dc.rights.holderUttaro, Antonio Domingoes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectCapsasporaes
dc.subjectSterol metabolismes
dc.subjectTranscriptional regulationes
dc.subjectOpisthokontses
dc.subjectCholesteroles
dc.subjectErgosteroles
dc.titleSterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animalses
dc.typepublishedVersion
dc.typepublishedVersion

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