Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
dc.citation.title | Molecules | es |
dc.citation.volume | 23(5) | es |
dc.creator | Méndez, Luciana | |
dc.creator | Poeylaut-Palena, Andrés A. | |
dc.creator | Mata, Ernesto Gabino | |
dc.date.accessioned | 2020-12-17T22:27:25Z | |
dc.date.available | 2020-12-17T22:27:25Z | |
dc.date.issued | 2018-05-16 | |
dc.description | The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary library, diversity was expanded by applying different cleavage conditions, leading to a series of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through incorporation of a chalcone moiety. | es |
dc.description | Para citar este articulo: Méndez, L.; Poeylaut-Palena, A.A.; Mata, E.G. Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives. Molecules 2018, 23, 1193. | |
dc.description.fil | Fil: Méndez, Luciana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina. | es |
dc.description.fil | Fil: Poeylaut-Palena, Andrés A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina. | es |
dc.description.fil | Fil: Mata, Ernesto Gabino. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina. | es |
dc.description.sponsorship | Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina (CONICET) | es |
dc.description.sponsorship | Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) | es |
dc.description.sponsorship | Universidad Nacional de Rosario (UNR) | es |
dc.format | application/pdf | |
dc.format.extent | 1-15 | es |
dc.identifier.issn | 1420-3049 | es |
dc.identifier.uri | http://hdl.handle.net/2133/19505 | |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.publisherversion | https://doi.org/10.3390/molecules23051193 | es |
dc.relation.publisherversion | https://www.mdpi.com/1420-3049/23/5/1193 | es |
dc.rights | openAccess | es |
dc.rights.holder | Universidad Nacional de Rosario | es |
dc.rights.holder | Méndez, Luciana | es |
dc.rights.holder | Poeylaut-Palena, Andrés A. | es |
dc.rights.holder | Mata, Ernesto Gabino | es |
dc.rights.text | Attribution 4.0 International (CC BY 4.0) | es |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Diversity-oriented Synthesis | es |
dc.subject | Solid-Phase Organic Synthesis | es |
dc.subject | beta-Lactam Derivatives | es |
dc.subject | Alkenes | es |
dc.subject | Metathesis | es |
dc.subject | Cholesterol Absorption Inhibitors | es |
dc.title | Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives | es |
dc.type | article | |
dc.type | artículo | |
dc.type | publishedVersion | |
dc.type.collection | articulo | |
dc.type.version | publishedVersion | es |