Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives

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dc.citation.titleMoleculeses
dc.citation.volume23(5)es
dc.creatorMéndez, Luciana
dc.creatorPoeylaut-Palena, Andrés A.
dc.creatorMata, Ernesto Gabino
dc.date.accessioned2020-12-17T22:27:25Z
dc.date.available2020-12-17T22:27:25Z
dc.date.issued2018-05-16
dc.descriptionThe application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary library, diversity was expanded by applying different cleavage conditions, leading to a series of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through incorporation of a chalcone moiety.es
dc.descriptionPara citar este articulo: Méndez, L.; Poeylaut-Palena, A.A.; Mata, E.G. Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives. Molecules 2018, 23, 1193.
dc.description.filFil: Méndez, Luciana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina.es
dc.description.filFil: Poeylaut-Palena, Andrés A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina.es
dc.description.filFil: Mata, Ernesto Gabino. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina.es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas de Argentina (CONICET)es
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT)es
dc.description.sponsorshipUniversidad Nacional de Rosario (UNR)es
dc.formatapplication/pdf
dc.format.extent1-15es
dc.identifier.issn1420-3049es
dc.identifier.urihttp://hdl.handle.net/2133/19505
dc.language.isoenges
dc.publisherMDPIes
dc.relation.publisherversionhttps://doi.org/10.3390/molecules23051193es
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/23/5/1193es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderMéndez, Lucianaes
dc.rights.holderPoeylaut-Palena, Andrés A.es
dc.rights.holderMata, Ernesto Gabinoes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectDiversity-oriented Synthesises
dc.subjectSolid-Phase Organic Synthesises
dc.subjectbeta-Lactam Derivativeses
dc.subjectAlkeneses
dc.subjectMetathesises
dc.subjectCholesterol Absorption Inhibitorses
dc.titleMolecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivativeses
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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