Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
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The application of the reagent-based diversification strategy for generation of libraries
of biologically promising β-lactam derivatives is described. Key features are the versatility of the
linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized
primary library, diversity was expanded by applying different cleavage conditions, leading to a series
of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through
incorporation of a chalcone moiety.
Para citar este articulo: Méndez, L.; Poeylaut-Palena, A.A.; Mata, E.G. Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives. Molecules 2018, 23, 1193.
Para citar este articulo: Méndez, L.; Poeylaut-Palena, A.A.; Mata, E.G. Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives. Molecules 2018, 23, 1193.
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