Action of Colloidal Bismuth Hydroxide Gel and its Commercial Cream on Enteropathogens and Colonizers of the Gastrointestinal Tract

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dc.citation.titleJournal of Global Infectious Diseases
dc.citation.volume1-6
dc.creatorSubils, Tomás
dc.creatorCasabonne, Cecilia
dc.creatorGonzález, Agustina
dc.creatorAquili, Virginia
dc.creatorBalagué, Claudia Elizabeth
dc.date.accessioned2024-04-10T12:33:46Z
dc.date.available2024-04-10T12:33:46Z
dc.date.issued2018-10
dc.description.abstractBackground: Acute diarrheal diseases constitute a world public health problem because they are the second cause of death in children under 5 years of age. Colloidal bismuth hydroxide gel (CBHG) is an active ingredient in low-cost, antidiarrhetic drugs for oral use; it does not inhibit intestinal motility, and it features very low intestinal absorption of <1%. Materials and Methods: We analyzed the sensitivity by determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC); the effect on bacterial growth by studying the specific growth velocity and the generation time in growth curves; and bacterial attachment by counting viable plaques, of enteropathogenic Escherichia coli, shigatoxigenic E. coli O157:H7, Klebsiella pneumoniae, Salmonella spp., and Shigella flexneri in the commercial cream (Chobet® bismuth cream with pectin [CBCHP]), its active ingredient (CBHG), and its excipients (E) separately. Results: CBCHP: MIC 6–10 mg/ml and MBC 7.5–15 mg/ml of bismuth; CBHG: MIC 6–10 mg/ml of bismuth. E: No inhibition was observed at the concentration studied in this study. At very low subinhibitory concentrations of CBCHP and CBHG, there was already evidence of a significant decrease in growth, which could not be recorded for E. CBCHP and CBHG presented an elevated capacity for bacterial displacement, significantly greater than E. Conclusions: We believed that the results obtained in this study are very promising from the treatment standpoint, as a possible treatment for cases of diagnosis or suspicion of bacterial gastroenteritis. The antimicrobial and attachment effects of CBCHP are exclusively due to its active ingredient CBHG; these effects are promoted in the presence of E.
dc.description.filFil: Subils, Tomás. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Casabonne, Cecilia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: González, Agustina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Aquili, Virginia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Balagué, Claudia Elizabeth. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.versionpeerreviewed
dc.identifier.e-issn0974-8245
dc.identifier.issn0974-777X
dc.identifier.urihttps://hdl.handle.net/2133/26862
dc.language.isoen
dc.publisherWolters Kluwer
dc.relation.publisherversionhttps://doi.org/10.4103/jgid.jgid_102_17
dc.relation.publisherversionhttps://journals.lww.com/jgid/fulltext/2018/10040/action_of_colloidal_bismuth_hydroxide_gel_and_its.8.aspx
dc.rightsopenAccess
dc.rights.holderSubils, Tomás
dc.rights.holderCasabonne, Cecilia
dc.rights.holderGonzález, Agustina
dc.rights.holderAquili, Virginia
dc.rights.holderBalagué, Claudia Elizabeth
dc.rights.holderUniversidad Nacional de Rosario
dc.rights.textAttribution-NonCommercial-ShareAlike 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectColloidal bismuth
dc.subjectDiarrhea
dc.subjectEnteropathogens
dc.titleAction of Colloidal Bismuth Hydroxide Gel and its Commercial Cream on Enteropathogens and Colonizers of the Gastrointestinal Tract
dc.typearticulo
dc.type.versionpublishedVersion

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