Miconazole Nitrate Microparticles in Lidocaine Loaded Films as a treatment for Oropharyngeal Candidiasis

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dc.citation.titleMaterials
dc.citation.volume16
dc.contributor.orcidhttps://orcid.org/0000-0002-4457-9099
dc.contributor.orcidhttps://orcid.org/0000-0003-1099-3686
dc.contributor.orcidhttps://orcid.org/0000-0002-4271-1690
dc.contributor.orcidhttps://orcid.org/0000-0002-4909-4592
dc.contributor.orcidhttps://orcid.org/0000-0003-2292-3570
dc.creatorTejada, Guillermo
dc.creatorCalvo, Natalia Lorena
dc.creatorMorri, Mauro
dc.creatorSortino, Maximiliano Andrés
dc.creatorLamas, María Celina
dc.creatorAlvarez, Vera A.
dc.creatorLeonardi, Darío
dc.date.accessioned2024-07-26T14:35:49Z
dc.date.available2024-07-26T14:35:49Z
dc.date.issued2023-05-07
dc.description.abstractOral candidiasis is an opportunistic infection that affects mainly individuals with weakened immune system. Devices used in the oral area to treat this condition include buccal films, which present advantages over both oral tablets and gels. Since candidiasis causes pain, burning, and itching, the purpose of this work was to develop buccal films loaded with both lidocaine (anesthetic) and miconazole nitrate (MN, antifungal) to treat this pathology topically. MN was loaded in microparticles based on different natural polymers, and then, these microparticles were loaded in hydroxypropyl methylcellulose-gelatin-based films containing lidocaine. All developed films showed adequate adhesiveness and thickness. DSC and XRD tests suggested that the drugs were in an amorphous state in the therapeutic systems. Microparticles based on chitosan-alginate showed the highest MN encapsulation. Among the films, those containing the mentioned microparticles presented the highest tensile strength and the lowest elongation at break, possibly due to the strong interactions between both polymers. These films allowed a fast release of lidocaine and a controlled release of MN. Due to the latter, these systems showed antifungal activity for 24 h. Therefore, the treatment of oropharyngeal candidiasis with these films could reduce the number of daily applications with respect to conventional treatments.
dc.description.filFil: Tejada, Guillermo. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Grupo Materiales Compuestos Termoplásticos; Argentina.
dc.description.filFil: Calvo, Natalia Lorena. Instituto de Química Rosario; Argentina.
dc.description.filFil: Calvo, Natalia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento Química Orgánica. Área de Análisis de Medicamentos; Argentina.
dc.description.filFil: Mauro Morri. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Planta Piloto de Producción de Medicamentos; Argentina.
dc.description.filFil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento Química Orgánica. Área Farmacognosia. Centro de Referencia de Micología; Argentina.
dc.description.filFil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento Química Orgánica. Área Farmacognosia; Argentina.
dc.description.filFil: Lamas, María Celina. Instituto de Química Rosario; Argentina.
dc.description.filFil: Lamas, María Celina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento Farmacia. Área Técnica Farmacéutica; Argentina.
dc.description.filFil: Alvarez, Vera A. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Grupo Materiales Compuestos Termoplásticos; Argentina.
dc.description.filFil: Leonardi, Darío. Instituto de Química Rosario; Argentina.
dc.description.filFil: Leonardi, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento Farmacia. Área Técnica Farmacéutica; Argentina.
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica: PICT 2017-1276
dc.format.extent1-14
dc.identifier.issn1996-1944
dc.identifier.urihttps://hdl.handle.net/2133/27474
dc.language.isoen
dc.publisherMDPI
dc.relation.publisherversionhttps://www.mdpi.com/1996-1944/16/9/3586
dc.relation.publisherversionhttps://doi.org/10.3390/ma16093586
dc.rightsopenAccess
dc.rights.holderTejada, Guillermo
dc.rights.holderCalvo, Natalia Lorena
dc.rights.holderMorri, Mauro
dc.rights.holderSortino, Maximiliano Andrés
dc.rights.holderLamas, María Celina
dc.rights.holderAlvarez, Vera A.
dc.rights.holderLeonardi, Darío
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 International CC BY 4.0 Deed
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectOropharyngeal candidiasis
dc.subjectMiconazole nitrate
dc.subjectLidocaine
dc.subjectPolymeric microparticles
dc.subjectPolymeric films
dc.titleMiconazole Nitrate Microparticles in Lidocaine Loaded Films as a treatment for Oropharyngeal Candidiasis
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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