Prevalence of human papillomavirus infection in Argentinean women attending two different hospitals prior to the implementation of the National vaccination program.

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dc.citation.titleJournal of Medical Virology
dc.citation.volume85(4)
dc.creatorChouhy, Diego
dc.creatorMamprín D´Andrea, Rubén
dc.creatorIglesias, Mercedes
dc.creatorMessina, Analía
dc.creatorIvancovich, Juan José
dc.creatorCerda, Belén
dc.creatorGalimberti, Diana
dc.creatorBottai, Hebe
dc.creatorGiri, Adriana Angélica
dc.date.accessioned2017-12-06T11:31:02Z
dc.date.available2017-12-06T11:31:02Z
dc.date.issued2013-04
dc.descriptionCervarix vaccine was included in the National Immunization Program of Argentina in 2011 but data about the local distribution of human papillomavirus (HPV) infection in women exposed to the virus are scarce. This cross-sectional study determined the prevalence and type distribution of HPV infection in unvaccinated women attending routine gynaecological screening in two public hospitals located in Buenos Aires and Santa Fe, Argentina. Socio-demographic, sexual behaviour and co-factors information was obtained from all participants (Buenos Aires, n=429; Santa Fe, n=433). Cervicovaginal swabs were tested with an MY11/09 primer-based assay and with the CUT primer system targeting mucosal/cutaneous HPVs. Participants from Buenos Aires showed significantly higher rates of HPV infection (52.4% vs. 40.6%), of multiple infections (24.2% vs. 16.4%), and of low-risk (20.3% vs. 13.9%) and highrisk types (44.1% vs. 33.3%) than those from Santa Fe. HPV-66 (Buenos Aires: 17%) and HPV-16 (Santa Fe: 8.5%) were the most prevalent types. Novel HPV-66 putative subtype and variants were identified. Vaccine types 16 and 18 were frequent (Buenos Aires: 13.5%; Santa Fe F: 10.2%) but few participants had co-infections with both (Buenos Aires: 1.4%; Santa Fe: 0.2%). A common risk factor for HPV infection was having a new sexual partner in the last year (Buenos Aires: OR 2.53, p<0.001; Santa Fe: OR 1.85, p=0.04). This study provides valuable baseline data for future assessment of the impact of massive vaccination in Argentina and it underlines the use of additional HPV testing strategies, such as the CUT system, for surveillance and vaccinology.es
dc.description.filFil: Chouhy, Diego. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área de Virología; Argentina
dc.description.filFil: Chouhy, Diego. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (UNR-CONICET); Argentina
dc.description.filFil: Mamprín D´Andrea, Rubén. Santa Fe. Ministerio de Salud. Hospital-Escuela “Eva Perón”. División de Ginecología; Argentina
dc.description.filFil: Iglesias, Mercedes. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos “Dr. Teodoro Alvarez”. Laboratorio Central; Argentina
dc.description.filFil: Messina, Analía. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos “Dr. Teodoro Alvarez”. Departamento de Obstetricia y Pediatría; Argentina
dc.description.filFil: Ivancovich, Juan José. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Estadística y Procesamiento de Datos; Argentina
dc.description.filFil: Cerda, Belén. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área de Virología; Argentina
dc.description.filFil: Galimberti, Diana. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos “Dr. Teodoro Alvarez”. Departamento de Obstetricia y Pediatría; Argentina
dc.description.filFil: Bottai, Hebe. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Estadística y Procesamiento de Datos; Argentina
dc.description.filFil: Giri, Adriana Angélica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área de Virología; Argentina
dc.description.filFil: Giri, Adriana Angélica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (UNR-CONICET); Argentina
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (Becas PICT 05-25464 y PICT 2008-0421)es
dc.description.sponsorshipFogarty International Center/NIH grant (Grant # D43 TW 001037)es
dc.formatapplication/pdf
dc.format.extent655–666
dc.identifier.doi10.1002/jmv.23509
dc.identifier.other1096-9071
dc.identifier.urihttp://hdl.handle.net/2133/9861
dc.language.isoenges
dc.publisherWileyes
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/jmv.23509/abstractes
dc.rightsopenAccesses
dc.rights.holderWileyes
dc.rights.holderChouhy, Diegoes
dc.rights.holderMamprín D´Andrea, Rubénes
dc.rights.holderIglesias, Mercedeses
dc.rights.holderMessina, Analíaes
dc.rights.holderIvancovich, Juan Josées
dc.rights.holderCerda, Belénes
dc.rights.holderGalimberti, Dianaes
dc.rights.holderBottai, Hebees
dc.rights.holderGiri, Adriana Angélicaes
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectArgentinaes
dc.subjectMY11/09 and CUT primerses
dc.subjectHPV-66 diversityes
dc.subjectCervical HPV infectiones
dc.subjectPrevaccinationes
dc.titlePrevalence of human papillomavirus infection in Argentinean women attending two different hospitals prior to the implementation of the National vaccination program.es

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