Assessment of Chemosensory Response to Volatile Compounds in Healthy, Aged, and Neurodegenerative Caenorhabditis elegans Models

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dc.citation.titleBio-protocol journal
dc.citation.volume13
dc.creatorGrau, Roberto Ricardo
dc.creatorCrespo, Cira
dc.date.accessioned2024-04-19T20:32:19Z
dc.date.available2024-04-19T20:32:19Z
dc.date.issued2023-05-05
dc.description.abstractA basic function of the nervous system is to confer the ability to detect external stimuli and generate appropriate behavioral and physiological responses. These can be modulated when parallel streams of information are provided to the nervous system and neural activity is appropriately altered. The nematode Caenorhabditis elegans utilizes a simple and well characterized neural circuit to mediate avoidance or attraction responses to stimuli, such as the volatile odorant octanol or diacetyl (DA), respectively. Aging and neurodegeneration constitute two important factors altering the ability to detect external signals and, therefore, changing behavior. Here, we present a modified protocol to assess avoidance or attraction responses to diverse stimuli in healthy individuals and Caenorhabditis elegans models associated with neurodegenerative diseases.
dc.description.filFil: Grau, Roberto Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Grau, Roberto Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Crespo, Cira. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
dc.description.sponsorshipFondo para la Investigación Científica y Tecnológica (FonCyT)
dc.description.sponsorshipPew Latin American Fellows Program in the Biomedical Sciences
dc.description.sponsorshipFulbright Committeen
dc.description.sponsorshipFundación Antorchas
dc.description.versionpeerreviewed
dc.format.extent1-9
dc.identifier.issn2331-8325
dc.identifier.urihttps://hdl.handle.net/2133/26914
dc.language.isoen
dc.publisherBio-protocol L.L.C.
dc.relation.publisherversionhttps://doi.org/10.21769/bioprotoc.4650
dc.relation.publisherversionhttps://bio-protocol.org/en/bpdetail?id=4650&type=0
dc.rightsopenAccess
dc.rights.holderGrau, Roberto Ricardo
dc.rights.holderCrespo, Cira
dc.rights.holderUniversidad Nacional de Rosario
dc.rights.textAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectCaenorhabditis elegans
dc.subjectBehavior
dc.subjectDiacetyl
dc.subjectOctanol
dc.subjectNeurodegenerative diseases
dc.titleAssessment of Chemosensory Response to Volatile Compounds in Healthy, Aged, and Neurodegenerative Caenorhabditis elegans Models
dc.typearticulo
dc.type.versionpublishedVersion

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