Omicron waves in Argentina: dynamics of SARS-CoV-2 lineages BA.1, BA.2 and the emerging BA.2.12.1 and BA.4/BA.5

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dc.citation.titleViruseses
dc.citation.volume15
dc.creatorTorres, Carolina
dc.creatorNabaes Jodar, Mercedes
dc.creatorAcuña, Dolores
dc.creatorZambrana Montaño, Romina Micaela
dc.creatorCulasso, Andrés Carlos Alberto
dc.creatorAmadio, Ariel Fernando
dc.creatorAulicino, Paula
dc.creatorCeballos, Santiago
dc.creatorCacciabue, Marco
dc.creatorDebat, Humberto
dc.creatorDus Santos, María José
dc.creatorEberhardt, María Florencia
dc.creatorEspul, Carlos
dc.creatorFay, Fabián
dc.creatorFernández, María Ailén
dc.creatorFernández, Franco
dc.creatorFernandez Muñoz, Juan Manuel
dc.creatorFerrini, Florencia
dc.creatorGallego, Fernando
dc.creatorGiri, Adriana Angélica
dc.creatorCerri, Agustina
dc.creatorBolatti, Elisa María
dc.creatorGismondi, María Ines
dc.creatorGoya, Stephanie
dc.creatorGramundi, Iván
dc.creatorIrazoqui, José Matías
dc.creatorKönig, Guido Alberto
dc.creatorLeiva, Viviana
dc.creatorLucero, Horacio
dc.creatorMarquez, Nathalie
dc.creatorNardi, Cristina
dc.creatorOrtiz, Belén
dc.creatorPianciola, Luis
dc.creatorPintos, Carolina Beatriz
dc.creatorPuebla, Andrea Fabiana
dc.creatorRastellini, Carolina Victoria
dc.creatorRojas, Alejandro Ezequiel
dc.creatorSfalcin, Javier
dc.creatorSuárez, Ariel
dc.creatorTittarelli, Estefanía
dc.creatorToro, Rosana
dc.creatorVillanova, Gabriela Vanina
dc.creatorZiehm, María Cecilia
dc.creatorZimmermann, María Carla
dc.creatorZunino, Sebastián
dc.creatorProyecto PAIS Working Group
dc.creatorValinotto, Laura
dc.creatorViegas, Mariana
dc.date.accessioned2023-04-03T15:25:03Z
dc.date.available2023-04-03T15:25:03Z
dc.date.issued2023-01-22
dc.descriptionThe COVID-19 pandemic has lately been driven by Omicron. This work aimed to study the dynamics of SARS-CoV-2 Omicron lineages during the third and fourth waves of COVID-19 in Argentina. Molecular surveillance was performed on 3431 samples from Argentina, between EW44/2021 and EW31/2022. Sequencing, phylogenetic and phylodynamic analyses were performed. A differential dynamic between the Omicron waves was found. The third wave was associated with lineage BA.1, characterized by a high number of cases, very fast displacement of Delta, doubling times of 3.3 days and a low level of lineage diversity and clustering. In contrast, the fourth wave was longer but associated with a lower number of cases, initially caused by BA.2, and later by BA.4/BA.5, with doubling times of about 10 days. Several BA.2 and BA.4/BA.5 sublineages and introductions were detected, although very few clusters with a constrained geographical distribution were observed, suggesting limited transmission chains. The differential dynamic could be due to waning immunity and an increase in population gatherings in the BA.1 wave, and a boosted population (for vaccination or recent prior immunity for BA.1 infection) in the wave caused by BA2/BA.4/BA.5, which may have limited the establishment of the new lineages.es
dc.description.filFil: Villanova, Gabriela Vanina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Biotecnología Acuática. Centro Científico Tecnológico y Educativo Acuario del río Paraná; Argentina.es
dc.description.sponsorshipMinisterio de Ciencia, Tecnología e Innovación, Argentina (MINCyT) : IP COVID-19 N°08
dc.description.sponsorshipFondo para la Convergencia Estructural del MERCOSUR (Focem): COF 03/11 Covid-19
dc.formatapplication/pdf
dc.format.extent1-13es
dc.identifier.issn1999-4915es
dc.identifier.urihttp://hdl.handle.net/2133/25429
dc.language.isoenges
dc.publisherMDPIes
dc.relation.publisherversionhttps://www.mdpi.com/1999-4915/15/2/312
dc.relation.publisherversionhttps://doi.org/10.3390/v15020312
dc.rightsopenAccesses
dc.rights.holderTorres, Carolinaes
dc.rights.holderNabaes Jodar, Mercedeses
dc.rights.holderAcuña, Doloreses
dc.rights.holderZambrana Montaño, Romina Micaelaes
dc.rights.holderCulasso, Andrés Carlos Albertoes
dc.rights.holderAmadio, Ariel Fernandoes
dc.rights.holderAulicino, Paulaes
dc.rights.holderCeballos, Santiagoes
dc.rights.holderCacciabue, Marcoes
dc.rights.holderDebat, Humbertoes
dc.rights.holderDus Santos, María Josées
dc.rights.holderEberhardt, María Florenciaes
dc.rights.holderEspul, Carloses
dc.rights.holderFay, Fabiánes
dc.rights.holderFernández; María Ailénes
dc.rights.holderFernández, Francoes
dc.rights.holderFernandez Muñoz, Juan Manueles
dc.rights.holderFerrini, Florenciaes
dc.rights.holderGallego, Fernandoes
dc.rights.holderGiri, Adriana Angélicaes
dc.rights.holderCerri, Agustinaes
dc.rights.holderBolatti, Elisa Maríaes
dc.rights.holderGismondi, María Ineses
dc.rights.holderGoya, Stephaniees
dc.rights.holderGramundi, Ivánes
dc.rights.holderIrazoqui, José Matíases
dc.rights.holderKönig, Guido Albertoes
dc.rights.holderLeiva, Vivianaes
dc.rights.holderLucero, Horacioes
dc.rights.holderMarquez, Nathaliees
dc.rights.holderNardi, Cristinaes
dc.rights.holderOrtiz, Belénes
dc.rights.holderPianciola, Luises
dc.rights.holderPintos, Carolina Beatrizes
dc.rights.holderPuebla, Andrea Fabianaes
dc.rights.holderRastellini, Carolina Victoriaes
dc.rights.holderRojas, Alejandro Ezequieles
dc.rights.holderSfalcin, Javieres
dc.rights.holderSuárez, Arieles
dc.rights.holderTittarelli, Estefaníaes
dc.rights.holderToro, Rosanaes
dc.rights.holderVillanova, Gabriela Vaninaes
dc.rights.holderZiehm, María Ceciliaes
dc.rights.holderZimmermann, María Carlaes
dc.rights.holderZunino, Sebastiánes
dc.rights.holderProyecto PAIS Working Groupes
dc.rights.holderValinotto, Lauraes
dc.rights.holderViegas, Marianaes
dc.rights.holderUniversidad Nacional de Rosario
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectSARS-CoV-2es
dc.subjectOmicrones
dc.subjectSouth Americaes
dc.subjectBA.1es
dc.subjectBA.2es
dc.subjectBA.4es
dc.subjectBA.5es
dc.titleOmicron waves in Argentina: dynamics of SARS-CoV-2 lineages BA.1, BA.2 and the emerging BA.2.12.1 and BA.4/BA.5es
dc.typepublishedVersion
dc.typearticle
dc.typeartículo
dc.type.collectionarticle
dc.type.versionpublishedVersion

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