Omicron waves in Argentina: dynamics of SARS-CoV-2 lineages BA.1, BA.2 and the emerging BA.2.12.1 and BA.4/BA.5
Cargando...
Fecha
Título de la revista
ISSN de la revista
Título del volumen
Editor
MDPI
Resumen
Descripción
The COVID-19 pandemic has lately been driven by Omicron. This work aimed to study
the dynamics of SARS-CoV-2 Omicron lineages during the third and fourth waves of COVID-19
in Argentina. Molecular surveillance was performed on 3431 samples from Argentina, between
EW44/2021 and EW31/2022. Sequencing, phylogenetic and phylodynamic analyses were performed.
A differential dynamic between the Omicron waves was found. The third wave was associated with
lineage BA.1, characterized by a high number of cases, very fast displacement of Delta, doubling times
of 3.3 days and a low level of lineage diversity and clustering. In contrast, the fourth wave was longer
but associated with a lower number of cases, initially caused by BA.2, and later by BA.4/BA.5, with
doubling times of about 10 days. Several BA.2 and BA.4/BA.5 sublineages and introductions were
detected, although very few clusters with a constrained geographical distribution were observed,
suggesting limited transmission chains. The differential dynamic could be due to waning immunity
and an increase in population gatherings in the BA.1 wave, and a boosted population (for vaccination
or recent prior immunity for BA.1 infection) in the wave caused by BA2/BA.4/BA.5, which may have
limited the establishment of the new lineages.
Palabras clave
Citación
Aprobación
Revisión
Complementado por
Referenciado por
Licencia Creative Commons
Excepto donde se indique lo contrario, la licencia de este ítem se describe como Attribution 4.0 International (CC BY 4.0)