Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells

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dc.contributor.authorRozados, Viviana R.
dc.contributor.authorHinrichsen, Lucila Isabel
dc.contributor.authorMcDonnel, José
dc.contributor.authorScharovsky, O. Graciela
dc.date.accessioned2012-07-12T14:58:33Z
dc.date.available2012-07-12T14:58:33Z
dc.date.issued1905-06-27
dc.description.abstractOur previous demonstration of an antimetastatic effect of lovastatin, both in rat sarcoma and lymphoma tumor-models, as well as the fact that lovastatin and radiation are able to stop the cell cycle in different phases, suggested the feasibility of a combined treatment. We studied the effect of the in vitro combined treatment of a B-cell rat lymphoma (L-TACB) with lovastatin and irradiation. The results herein obtained provide new information about the role of statins as radiosensitizers. The antitumor effect of the combined treatment was higher than that elicited by either treatment alone. This effect could be a consequence, at least in part, of an enhanced apoptosis.es
dc.description.peerreviewedPeer reviewedes
dc.formatapplication/pdf
dc.identifier.citationRozados VR, Hinrichsen LI, McDonnell J & Scharovsky O. G (2005) Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells. J Exp Clin Cancer Res 24:55–61.es
dc.identifier.issn0392-9078
dc.identifier.urihttp://hdl.handle.net/2133/1936
dc.language.isoenes
dc.publisherBioMed Central; "Regina Elena" National Cancer Institute, Italyes
dc.relation.publisherversionhttp://195.135.200.83/allegatiifo/rivista/anno2005/1/55.pdfes
dc.rightsopenAccess
dc.subject.meshLovastatin/pharmacology
dc.subject.meshAnimals
dc.subject.meshApoptosis/drug effects
dc.subject.meshApoptosis/radiation effects
dc.subject.meshB-Lymphocytes/drug effects
dc.subject.meshB-Lymphocytes/pathology
dc.subject.meshB-Lymphocytes/radiation effects
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshRats
dc.subject.meshTumor Cells, Cultured
dc.titleLovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cellses
dc.typearticle
dc.typeartículo
dc.typepublishedVersion

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