Biofilm proficient Bacillus subtilis prevents neurodegeneration in Caenorhabditis elegans Parkinson’s disease models via PMK-1/p38 MAPK and SKN-1/Nrf2 signaling

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dc.citation.titleScientific Reports
dc.citation.volume15
dc.creatorFrancisco, Marcos
dc.creatorGrau, Roberto Ricardo
dc.date.accessioned2025-04-09T13:20:54Z
dc.date.available2025-04-09T13:20:54Z
dc.date.issued2025-03-21
dc.description.abstractParkinson’s disease (PD) is a no-curable neurodegenerative disease of pandemic distribution for which only palliative treatments are available. A hallmark of PD is injury to dopaminergic neurons in the substantia nigra pars compacta. Here, we report that Caenorhabditis elegans colonized by biofilm-forming Bacillus subtilis is resistant to injury of dopaminergic neurons caused by treatment with the PD-related neurotoxin 6-hydroxydopamine (6-OHDA). Biofilm-forming B. subtilis-colonized C. elegans display dopamine-dependent behaviors indistinguishable from those of 6-OHDA-untreated worms colonized by gut commensal E. coli OP50. In C. elegans PD model strains with early dopaminergic neuron decay or overexpressing human alpha-synuclein, biofilm-forming B. subtilis colonization had neuroprotective effects and prevents alpha-synulcein aggregation, respectively. The B. subtilis-controlled insulin/IGF-1 signaling (ILS), whose downregulation prevents aging-related PD, is not involved in protecting against 6-OHDA-related injury. We demonstrate that biofilm-forming B. subtilis activates PMK-1 (p38 MAPK)/SKN-1 (Nrf2) signaling, which protects C. elegans from 6-OHDA-induced dopaminergic neuron injury.
dc.description.filFil: Francisco, Marcos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Francisco, Marcos. Kyojin Laboratories S.A.; Argentina.
dc.description.filFil: Francisco, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.filFil: Grau, Roberto Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina.
dc.description.filFil: Grau, Roberto Ricardo. Kyojin Laboratories S.A.; Argentina.
dc.description.filFil: Grau, Roberto Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.description.versionpeerreviewed
dc.format.extent1-15
dc.identifier.e-issn2045-2322
dc.identifier.urihttps://hdl.handle.net/2133/29248
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-025-93737-4
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-025-93737-4
dc.rightsopenAccess
dc.rights.holderFrancisco, Marcos
dc.rights.holderGrau, Roberto Ricardo
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCaenorhabditis elegans
dc.subjectBacillus subtilis
dc.subjectProbiotics
dc.subjectNrf2 signaling
dc.subjectParkinson disease
dc.titleBiofilm proficient Bacillus subtilis prevents neurodegeneration in Caenorhabditis elegans Parkinson’s disease models via PMK-1/p38 MAPK and SKN-1/Nrf2 signaling
dc.typearticulo
dc.type.versionpublishedVersion

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