Candida infections, causes, targets, and resistance mechanisms: traditional and alternative antifungal agents

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dc.citation.titleBioMed Research International
dc.citation.volume1-14
dc.citation.volume2013
dc.contributor.orcidhttps://orcid.org/0000-0003-2292-3570
dc.creatorSpampinato, Claudia P.
dc.creatorLeonardi, Darío
dc.date.accessioned2024-04-12T14:18:32Z
dc.date.available2024-04-12T14:18:32Z
dc.date.issued2013
dc.description.abstractThe genus Candida includes about 200 different species, but only a few species are human opportunistic pathogens and cause infections when the host becomes debilitated or immunocompromised.Candida infections can be superficial or invasive. Superficial infections often affect the skin or mucous membranes and can be treated successfully with topical antifungal drugs. However, invasive fungal infections are often life-threatening, probably due to inefficient diagnostic methods and inappropriate initial antifungal therapies. Here, we briefly review our current knowledge of pathogenic species of the genus Candida and yeast infection causes and then focus on current antifungal drugs and resistance mechanisms. An overview of new therapeutic alternatives for the treatment of Candida infections is also provided.
dc.description.filFil: Spampinato, Claudia P. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Biológica; Argentina.
dc.description.filFil: Spampinato, Claudia P. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Fotosintéticos y Bioquímicos (CONICET-CEFOBI); Argentina.
dc.description.filFil: Leonardi, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Tecnología Farmacéutica; Argentina.
dc.description.filFil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT 0458, PICT 2643
dc.description.sponsorshipConsejo Nacional de Investigaciones Cientrıficas y Técnicas (CONICET): PIP 0018
dc.description.sponsorshipUniversidad Nacional de Rosario (UNR): BIO 221, BIO 328
dc.identifier.issn2314-6141
dc.identifier.urihttps://hdl.handle.net/2133/26873
dc.language.isoen
dc.publisherHindawi
dc.relation.publisherversionhttps://www.hindawi.com/journals/bmri/2013/204237/
dc.relation.publisherversionhttps://doi.org/10.1155/2013/204237
dc.rightsopenAccess
dc.rights.holderSpampinato, Claudia P.
dc.rights.holderLeonardi, Darío
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAntifungal agents
dc.subjectCandida
dc.subjectCandidiasis
dc.subjectDrug resistance
dc.titleCandida infections, causes, targets, and resistance mechanisms: traditional and alternative antifungal agents
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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