Neuroprotective effect of NSCs-derived extracellular vesicles in Parkinson's disease models

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dc.citation.titleScientific Reports
dc.citation.volume15
dc.contributor.otherDr. Wolozin, Benjamin: provide the WT/A53T α-syn DNA construct
dc.creatorDíaz Reyes, Mercyleidi
dc.creatorGatti, Sabrina
dc.creatorDelgado Ocaña, Susana
dc.creatorOrtega, Hugo H.
dc.creatorBanchio, Claudia
dc.date.accessioned2025-03-27T13:17:22Z
dc.date.available2025-03-27T13:17:22Z
dc.date.issued2025-02-19
dc.description.abstractParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms, caused by the degeneration and loss of dopaminergic neurons in the substantia nigra. Current therapies are limited to symptom management, unable to prevent neuronal loss or halt the progression of the disease. A significant limitation to more effective treatments is the difficulty of crossing the blood-brain barrier (BBB). Extracellular vesicles (EVs) communication plays a crucial role in several physiological processes within the nervous system. Notably, EVs have the unique ability to cross the BBB, making them a highly promising vehicle for delivering therapeutic agents directly to the brain. Given the rising prevalence of PD, the need for therapies that prevent neuronal death and promote cell survival is urgent. This study explores the potential of neural stem cell-derived extracellular vesicles (NSC-EVs) using two in vitro models of PD. Our findings demonstrate that NSC-EVs significantly enhance the survival of dopaminergic neurons by reducing apoptosis and showing strong neuroprotective effects. Notably, the natural extracellular vesicles used in this study are enriched with Catalase, a potent scavenger protein with antioxidant properties. This natural enrichment further strengthens their neuroprotective capacity, enabling them to mitigate oxidative stress and protect vulnerable neurons. The use of such naturally enriched extracellular vesicles represents a promising approach for developing innovative therapies to effectively combat Parkinson’s disease.
dc.description.filFil: Díaz Reyes, Mercyleidi. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Biológicas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET). Laboratorio de Biología Molecular y Celular de Lípidos.; Argentina.
dc.description.filFil: Gatti, Sabrina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Biológicas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET). Laboratorio de Biología Molecular y Celular de Lípidos.; Argentina.
dc.description.filFil: Delgado Ocaña, Susana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Biológicas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET). Laboratorio de Biología Molecular y Celular de Lípidos.; Argentina.
dc.description.filFil: Ortega, Hugo H. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral (ICiVet Litoral-CONICET). Centro de Medicina Comparada (CMC); Argentina.
dc.description.filFil: Banchio, Claudia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Biológicas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET). Laboratorio de Biología Molecular y Celular de Lípidos; Argentina.
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
dc.description.sponsorshipAgencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Agencia I+D+i): PICT 2019-01073
dc.description.versionpeerreviewed
dc.format.extent1-15
dc.identifier.e-issn2045-2322
dc.identifier.urihttps://hdl.handle.net/2133/29126
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-025-87238-7
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-025-87238-7
dc.rightsopenAccess
dc.rights.holderDíaz Reyes, Mercyleidi
dc.rights.holderGatti, Sabrina
dc.rights.holderDelgado Ocaña, Susana
dc.rights.holderOrtega, Hugo H.
dc.rights.holderBanchio, Claudia
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNeurodegenerative diseases
dc.subjectParkinson disease
dc.subjectDopaminergic neurons
dc.subjectBlood-brain barrier
dc.subjectExtracellular vesicles
dc.subjectNeural stem cells (NSC)
dc.subjectCatalase
dc.subjectOxidative stress
dc.subjectCell therapy
dc.subjectCell survival
dc.subjectNeuroprotection
dc.titleNeuroprotective effect of NSCs-derived extracellular vesicles in Parkinson's disease models
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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