N-heterocyclic carbene iron complexes as anticancer agents: In vitro and in vivo biological studies

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dc.citation.titleMoleculeses
dc.citation.volume26
dc.creatorLenis-Rojas, Oscar A.
dc.creatorCordeiro, Sandra
dc.creatorHorta-Meireles, Marta
dc.creatorAraujo Fernández, Jhonathan Angel
dc.creatorFernández Vila, Sabela
dc.creatorRubiolo, Juan Andrés
dc.creatorCabezas-Sainz, Pablo
dc.creatorSanchez, Laura
dc.creatorFernandes, Alexandra R.
dc.creatorRoyo, Beatriz
dc.date.accessioned2022-03-25T18:24:15Z
dc.date.available2022-03-25T18:24:15Z
dc.date.issued2021-09-12
dc.descriptionCisplatin and its derivatives are commonly used in chemotherapeutic treatments of cancer, even though they suffer from many toxic side effects. The problems that emerge from the use of these metal compounds led to the search for new complexes capable to overcome the toxic side effects. Here, we report the evaluation of the antiproliferative activity of Fe(II) cyclopentadienyl complexes bearing n-heterocyclic carbene ligands in tumour cells and their in vivo toxicological profile. The in vitro antiproliferative assays demonstrated that complex Fe1 displays the highest cytotoxic activity both in human colorectal carcinoma cells (HCT116) and ovarian carcinoma cells (A2780) with IC50 values in the low micromolar range. The antiproliferative effect of Fe1 was even higher than cisplatin. Interestingly, Fe1 showed low in vivo toxicity, and in vivo analyses of Fe1 and Fe2 compounds using colorectal HCT116 zebrafish xenograft showed that both reduce the proliferation of human HCT116 colorectal cancer cells in vivo.es
dc.description.filFil: Lenis-Rojas, Oscar A. Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA); Portugal.es
dc.description.filFil: Cordeiro, Sandra. NOVA University. Departamento Ciências da Vida. NOVA School of Science and Technology. UCIBIO; Portugal.es
dc.description.filFil: Cordeiro, Sandra. NOVA University. NOVA School of Science and Technology. Institute for Health and Bioeconomy; Portugal.es
dc.description.filFil: Horta-Meireles, Marta. Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA); Portugal.es
dc.description.filFil: Araujo Fernández, Jhonathan Angel. Universidad de Santiago de Compostela. Facultad de Veterinaria. Departamento de Zoología Genética y Antropología Física; Spain.es
dc.description.filFil: Araujo Fernández, Jhonathan Angel. University of Campinas. Department of Medical Genetics and Genomic Medicine. School of Medical Sciences. Laboratory of Zebrafish; Brazil.es
dc.description.filFil: Fernández Vila, Sabela. Universidad de Santiago de Compostela. Facultad de Veterinaria. Departamento de Zoología Genética y Antropología Física; Spain.es
dc.description.filFil: Rubiolo, Juan Andrés. Universidad de Santiago de Compostela. Facultad de Veterinaria. Departamento de Zoología Genética y Antropología Física; Spain.es
dc.description.filFil: Rubiolo, Juan Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro Científico y Tecnológico Acuario del Río Paraná; Argentina.es
dc.description.filFil: Cabezas-Sainz, Pablo. Universidad de Santiago de Compostela. Facultad de Veterinaria. Departamento de Zoología Genética y Antropología Física; Spain.es
dc.description.filFil: Sanchez, Laura. Universidad de Santiago de Compostela. Facultad de Veterinaria. Departamento de Zoología Genética y Antropología Física; Spain.es
dc.description.filFil: Sanchez, Laura. Health Research Institute of Santiago de Compostela. Preclinical Animal Models Group; Spain.es
dc.description.filFil: Fernandes, Alexandra R. NOVA University. Departamento Ciências da Vida. NOVA School of Science and Technology. UCIBIO; Portugal.es
dc.description.filFil: Fernandes, Alexandra R. NOVA University. NOVA School of Science and Technology. Institute for Health and Bioeconomy; Portugal.es
dc.description.filFil: Royo, Beatriz. Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA); Portugal.es
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT): Project MOSTMICRO-ITQB, UIDB/04612/2020, UIDP/04612/2020, Project LISBOA-01-0145-FEDER-007660
dc.description.sponsorshipApplied Molecular Biosciences Unit (UCIBIO): FCT UIDP/04378/2020, UIDB/04378/2020
dc.formatapplication/pdf
dc.format.extent1-14es
dc.identifier.issn1420-3049es
dc.identifier.urihttp://hdl.handle.net/2133/23256
dc.language.isoenges
dc.publisherMDPIes
dc.relation.publisherversionhttps://doi.org/10.3390/molecules26185535
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/26/18/5535
dc.rightsopenAccesses
dc.rights.holderLenis-Rojas, Oscar A.es
dc.rights.holderCordeiro, Sandraes
dc.rights.holderHorta-Meireles, Martaes
dc.rights.holderAraujo Fernández, Jhonathan Angeles
dc.rights.holderFernández Vila, Sabelaes
dc.rights.holderRubiolo, Juan Andréses
dc.rights.holderCabezas-Sainz, Pabloes
dc.rights.holderSanchez, Lauraes
dc.rights.holderFernandes, Alexandra R.es
dc.rights.holderRoyo, Beatrizes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectN-heterocyclic carbenees
dc.subjectIron(II)–NHC complexeses
dc.subjectAnticancer activityes
dc.subjectZebrafishes
dc.titleN-heterocyclic carbene iron complexes as anticancer agents: In vitro and in vivo biological studieses
dc.typepublishedVersion
dc.typearticle
dc.typeartículo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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