PER-14, a β-lactamase variant with reduced sensitivity to avibactam and relebactam

PER-1-producing Pseudomonas and Acinetobacter and PER-2-producingEnterobacterales, respectively, are increasingly difficult to treat due to combinedresistance to antibiotics like ceftazidime, cefiderocol, and ceftazidime/aztreonam-avibactam, among others. PER-14 differs from PER-2 by an S130T substitution. Throughcombined functional and in silico analyses, we demonstrated that PER-14 is resistant toavibactam and relebactam inhibition while retaining an extended-spectrum activity andthe ability to hydrolyze cefiderocol, as the S130T substitution affects the proper bindingof the DBOs.

Keywords

Pararheinheimera, Ceftazidime/avibactam, Ceftazidimase, ESBL, Diazabicyclooctane, Aztreonam/relebactam

Citation

Ruggiero, M., García Alonso, M., Drusin, S. I., Figueroa-Espinosa, R., Briceño Muñoz, I. J., Bonomo, R. A., Gutkind, G., Di Conza, J., Moreno, D. M., & Power, P. (2026). PER-14, a β-lactamase variant with reduced sensitivity to avibactam and relebactam. Antimicrobial Agents and Chemotherapy, 70(9), e00378-26. https://doi.org/10.1128/AAC.00378-26

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https://hdl.handle.net/2133/34144

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(FBIOyF) Departamento de Microbiología - Artículos

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PER-14, a β-lactamase variant with reduced sensitivity to avibactam and relebactam

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