Brains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfishes
dc.citation.title | Biology | es |
dc.citation.volume | 10 | |
dc.creator | Guerrero Peña, Laura | |
dc.creator | Suarez Bregua, Paula | |
dc.creator | Méndez Martínez, Luis | |
dc.creator | García Fernández, Pablo | |
dc.creator | Tur, Ricardo | |
dc.creator | Rubiolo, Juan Andrés | |
dc.creator | Tena, Juan J. | |
dc.creator | Rotllant, Josep | |
dc.date.accessioned | 2022-04-07T20:23:50Z | |
dc.date.available | 2022-04-07T20:23:50Z | |
dc.date.issued | 2021-12-02 | |
dc.description | Metamorphosis is a captivating process of change during which the morphology of the larva is completely reshaped to face the new challenges of adult life. In the case of fish, this process initiated in the brain has traditionally been considered to be a critical rearing point and despite the pioneering molecular work carried out in other flatfishes, the underlying molecular basis is still relatively poorly characterized. Turbot brain transcriptome of three developmental stages (pre-metamorphic, climax of metamorphosis and post-metamorphic) were analyzed to study the gene expression dynamics throughout the metamorphic process. A total of 1570 genes were differentially expressed in the three developmental stages and we found a specific pattern of gene expression at each stage. Unexpectedly, at the climax stage of metamorphosis, we found highly expressed genes related to the immune response, while the biological pathway enrichment analysis in pre-metamorphic and post-metamorphic were related to cell differentiation and oxygen carrier activity, respectively. In addition, our results confirm the importance of thyroid stimulating hormone, increasing its expression during metamorphosis. Based on our findings, we assume that immune system activation during the climax of metamorphosis stage could be related to processes of larval tissue inflammation, resorption and replacement, as occurs in other vertebrates. | es |
dc.description.fil | Fil: Guerrero Peña, Laura. Spanish National Research Council. Institute of Marine Research. Aquatic Biotechnology Lab; Spain. | es |
dc.description.fil | Fil: Suarez Bregua, Paula. Spanish National Research Council. Institute of Marine Research. Aquatic Biotechnology Lab; Spain. | es |
dc.description.fil | Fil: Méndez Martínez, Luis. Spanish National Research Council. Institute of Marine Research. Aquatic Biotechnology Lab; Spain. | es |
dc.description.fil | Fil: García Fernández, Pablo. Nueva Pescanova Biomarine Center; Spain. | es |
dc.description.fil | Fil: Tur, Ricardo. Nueva Pescanova Biomarine Center; Spain. | es |
dc.description.fil | Fil: Rubiolo, Juan Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro Científico y Tecnológico Acuario del Río Paraná; Argentina. | es |
dc.description.fil | Fil: Rubiolo, Juan Andrés. Universidad de Santiago de Compostela. Facultad de Veterinaria. Departamento de Genética; Spain. | es |
dc.description.fil | Fil: Tena, Juan J. Universidad Pablo de Olavide. Centro Andaluz de Biología del Desarrollo (CABD); Spain. | es |
dc.description.fil | Fil: Rotllant, Josep. Spanish National Research Council. Institute of Marine Research. Aquatic Biotechnology Lab; Spain. | es |
dc.description.sponsorship | European Regional Development Fund (ERDF) | |
dc.description.sponsorship | Xunta de Galicia: IN606A-2020/006 | |
dc.description.sponsorship | Ministerio de Economía y Competitividad: PRE2018-085475 | |
dc.format | application/pdf | |
dc.format.extent | 1-16 | es |
dc.identifier.issn | 2079-7737 | es |
dc.identifier.uri | http://hdl.handle.net/2133/23342 | |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.publisherversion | https://doi.org/10.3390/biology10121256 | |
dc.relation.publisherversion | https://www.mdpi.com/2079-7737/10/12/1256 | |
dc.rights | openAccess | es |
dc.rights.holder | Guerrero Peña, Laura | es |
dc.rights.holder | Suarez Bregua, Paula | es |
dc.rights.holder | Méndez Martínez, Luis | es |
dc.rights.holder | García Fernández, Pablo | es |
dc.rights.holder | Tur, Ricardo | es |
dc.rights.holder | Rubiolo, Juan Andrés | es |
dc.rights.holder | Tena, Juan J. | es |
dc.rights.holder | Rotllant, Josep | es |
dc.rights.text | Attribution 4.0 International (CC BY 4.0) | es |
dc.rights.uri | http://creativecommons.org/licenses/by/2.5/ar/ | * |
dc.subject | Turbot | es |
dc.subject | Metamorphosis | es |
dc.subject | Brain | es |
dc.subject | RNA | es |
dc.subject | Sequencing | es |
dc.subject | Transcriptome | es |
dc.title | Brains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfishes | es |
dc.type | publishedVersion | |
dc.type | article | |
dc.type | artículo | |
dc.type.collection | articulo | |
dc.type.version | publishedVersion |
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