Brains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfishes

Vista sencilla de ítem
dc.citation.titleBiologyes
dc.citation.volume10
dc.creatorGuerrero Peña, Laura
dc.creatorSuarez Bregua, Paula
dc.creatorMéndez Martínez, Luis
dc.creatorGarcía Fernández, Pablo
dc.creatorTur, Ricardo
dc.creatorRubiolo, Juan Andrés
dc.creatorTena, Juan J.
dc.creatorRotllant, Josep
dc.date.accessioned2022-04-07T20:23:50Z
dc.date.available2022-04-07T20:23:50Z
dc.date.issued2021-12-02
dc.descriptionMetamorphosis is a captivating process of change during which the morphology of the larva is completely reshaped to face the new challenges of adult life. In the case of fish, this process initiated in the brain has traditionally been considered to be a critical rearing point and despite the pioneering molecular work carried out in other flatfishes, the underlying molecular basis is still relatively poorly characterized. Turbot brain transcriptome of three developmental stages (pre-metamorphic, climax of metamorphosis and post-metamorphic) were analyzed to study the gene expression dynamics throughout the metamorphic process. A total of 1570 genes were differentially expressed in the three developmental stages and we found a specific pattern of gene expression at each stage. Unexpectedly, at the climax stage of metamorphosis, we found highly expressed genes related to the immune response, while the biological pathway enrichment analysis in pre-metamorphic and post-metamorphic were related to cell differentiation and oxygen carrier activity, respectively. In addition, our results confirm the importance of thyroid stimulating hormone, increasing its expression during metamorphosis. Based on our findings, we assume that immune system activation during the climax of metamorphosis stage could be related to processes of larval tissue inflammation, resorption and replacement, as occurs in other vertebrates.es
dc.description.filFil: Guerrero Peña, Laura. Spanish National Research Council. Institute of Marine Research. Aquatic Biotechnology Lab; Spain.es
dc.description.filFil: Suarez Bregua, Paula. Spanish National Research Council. Institute of Marine Research. Aquatic Biotechnology Lab; Spain.es
dc.description.filFil: Méndez Martínez, Luis. Spanish National Research Council. Institute of Marine Research. Aquatic Biotechnology Lab; Spain.es
dc.description.filFil: García Fernández, Pablo. Nueva Pescanova Biomarine Center; Spain.es
dc.description.filFil: Tur, Ricardo. Nueva Pescanova Biomarine Center; Spain.es
dc.description.filFil: Rubiolo, Juan Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro Científico y Tecnológico Acuario del Río Paraná; Argentina.es
dc.description.filFil: Rubiolo, Juan Andrés. Universidad de Santiago de Compostela. Facultad de Veterinaria. Departamento de Genética; Spain.es
dc.description.filFil: Tena, Juan J. Universidad Pablo de Olavide. Centro Andaluz de Biología del Desarrollo (CABD); Spain.es
dc.description.filFil: Rotllant, Josep. Spanish National Research Council. Institute of Marine Research. Aquatic Biotechnology Lab; Spain.es
dc.description.sponsorshipEuropean Regional Development Fund (ERDF)
dc.description.sponsorshipXunta de Galicia: IN606A-2020/006
dc.description.sponsorshipMinisterio de Economía y Competitividad: PRE2018-085475
dc.formatapplication/pdf
dc.format.extent1-16es
dc.identifier.issn2079-7737es
dc.identifier.urihttp://hdl.handle.net/2133/23342
dc.language.isoenges
dc.publisherMDPIes
dc.relation.publisherversionhttps://doi.org/10.3390/biology10121256
dc.relation.publisherversionhttps://www.mdpi.com/2079-7737/10/12/1256
dc.rightsopenAccesses
dc.rights.holderGuerrero Peña, Lauraes
dc.rights.holderSuarez Bregua, Paulaes
dc.rights.holderMéndez Martínez, Luises
dc.rights.holderGarcía Fernández, Pabloes
dc.rights.holderTur, Ricardoes
dc.rights.holderRubiolo, Juan Andréses
dc.rights.holderTena, Juan J.es
dc.rights.holderRotllant, Josepes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/ar/*
dc.subjectTurbotes
dc.subjectMetamorphosises
dc.subjectBraines
dc.subjectRNAes
dc.subjectSequencinges
dc.subjectTranscriptomees
dc.titleBrains in metamorphosis: Temporal transcriptome dynamics in hatchery-reared flatfisheses
dc.typepublishedVersion
dc.typearticle
dc.typeartículo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

Archivos

Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Brains-in-metamorphosis-Temporal-transcriptome-dynamics-in-hatcheryreared-flatfishesBiology.pdf
Tamaño:
4.21 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
Nombre:
license.txt
Tamaño:
3.59 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

(FBIOyF) Departamento de Ciencias Biológicas - Artículo de Revista