Selected aspects of the analytical and pharmaceutical profiles of Nifurtimox

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dc.citation.titleJournal of Pharmaceutical Sciences
dc.citation.volume112
dc.creatorMoroni, Aldana Beatriz
dc.creatorCalvo, Natalia Lorena
dc.creatorKaufman, Teodoro Saúl
dc.date.accessioned2024-09-23T13:10:03Z
dc.date.available2024-09-23T13:10:03Z
dc.date.issued2023-02-16
dc.description.abstractNifurtimox is a nitroheterocyclic drug employed for treatment of trypanosomiases (Chagas disease and West African sleeping sickness); its use for certain cancers has also been assessed. Despite having been in the market for over 50 years, knowledge of nifurtimox is still fragmentary and incomplete. Relevant aspects of the chemistry and biology of nifurtimox are reviewed to summarize the current knowledge of this drug. These comprise its chemical synthesis and the preparation of some analogues, as well as its chemical degradation. Selected physical data and physicochemical properties are also listed, along with different approaches toward the analytical characterization of the drug, including electrochemical (polarography, cyclic voltammetry), spectroscopic (ultraviolet-visible, nuclear magnetic resonance, electron spin resonance), and single crystal X-ray diffractometry. The array of polarographic, ultraviolet-visible spectroscopic, and chromatographic methods available for the analytical determination of nifurtimox (in bulk drug, pharmaceutical formulations, and biological samples), are also presented and discussed, along with chiral chromatographic and electrophoretic alternatives for the separation of the enantiomers of the drug. Aspects of the drug likeliness of nifurtimox, its classification in the Biopharmaceutical Classification System, and available pharmaceutical formulations are detailed, whereas pharmacological, chemical, and biological aspects of its metabolism and disposition are discussed.
dc.description.filFil: Moroni, Aldana Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET). Área de Análisis de Medicamentos; Argentina.
dc.description.filFil: Calvo, Natalia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET). Área de Análisis de Medicamentos; Argentina.
dc.description.filFil: Kaufman, Teodoro Saúl. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET). Área de Análisis de Medicamentos; Argentina.
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PUE IQUIR 2016
dc.description.sponsorshipAgencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Agencia I+D+i): PICT 2019-1155
dc.description.sponsorshipAgencia Santafesina de Ciencia Tecnología e Innovación (ASaCTeI): IO-2019-302
dc.description.versionpeerreviewed
dc.format.extent1-16
dc.identifier.citationMoroni, A. B., Calvo, N. L. and Kaufman, T. S. (2023). Selected Aspects of the Analytical and Pharmaceutical Profiles of Nifurtimox. Journal of Pharmaceutical Sciences, 112(6), 1523-1538. https://doi.org/10.1016/j.xphs.2023.02.015
dc.identifier.e-issn1520-6017
dc.identifier.issn0022-3549
dc.identifier.urihttps://hdl.handle.net/2133/27842
dc.language.isoen
dc.publisherElsevier
dc.relation.publisherversionhttps://doi.org/10.1016/j.xphs.2023.02.015
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0022354923000679?via%3Dihub
dc.rightsembargoedAccess
dc.rights.holderMoroni, Aldana Beatriz
dc.rights.holderCalvo, Natalia Lorena
dc.rights.holderKaufman, Teodoro Saúl
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.holderElsevier
dc.rights.holderAmerican Pharmacists Association
dc.rights.textAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAnalytical chemistry
dc.subjectBCS
dc.subjectNifurtimox
dc.subjectMetabolism
dc.subjectPhysical characterization
dc.titleSelected aspects of the analytical and pharmaceutical profiles of Nifurtimox
dc.typearticulo
dc.type.versionacceptedVersion

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